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Research ArticleNeurology

18F-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test–Retest Reproducibility and Quantification of Neuroinflammation

Julie Ottoy, Livia De Picker, Jeroen Verhaeghe, Steven Deleye, Leonie wyffels, Lauren Kosten, Bernard Sabbe, Violette Coppens, Maarten Timmers, Luc van Nueten, Sarah Ceyssens, Sigrid Stroobants, Manuel Morrens and Steven Staelens
Journal of Nuclear Medicine August 2018, 59 (8) 1267-1274; DOI: https://doi.org/10.2967/jnumed.117.203315
Julie Ottoy
1Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium
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Livia De Picker
2Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium
3University Department of Psychiatry, Campus Duffel, Duffel, Belgium
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Jeroen Verhaeghe
1Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium
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Steven Deleye
1Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium
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Leonie wyffels
4Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium
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Lauren Kosten
1Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium
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Bernard Sabbe
2Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium
3University Department of Psychiatry, Campus Duffel, Duffel, Belgium
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Violette Coppens
2Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium
3University Department of Psychiatry, Campus Duffel, Duffel, Belgium
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Maarten Timmers
5Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium; and
6Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
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Luc van Nueten
5Janssen Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium; and
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Sarah Ceyssens
4Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium
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Sigrid Stroobants
4Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium
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Manuel Morrens
2Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium
3University Department of Psychiatry, Campus Duffel, Duffel, Belgium
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Steven Staelens
1Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium
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Journal of Nuclear Medicine: 59 (8)
Journal of Nuclear Medicine
Vol. 59, Issue 8
August 1, 2018
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18F-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test–Retest Reproducibility and Quantification of Neuroinflammation
Julie Ottoy, Livia De Picker, Jeroen Verhaeghe, Steven Deleye, Leonie wyffels, Lauren Kosten, Bernard Sabbe, Violette Coppens, Maarten Timmers, Luc van Nueten, Sarah Ceyssens, Sigrid Stroobants, Manuel Morrens, Steven Staelens
Journal of Nuclear Medicine Aug 2018, 59 (8) 1267-1274; DOI: 10.2967/jnumed.117.203315

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18F-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test–Retest Reproducibility and Quantification of Neuroinflammation
Julie Ottoy, Livia De Picker, Jeroen Verhaeghe, Steven Deleye, Leonie wyffels, Lauren Kosten, Bernard Sabbe, Violette Coppens, Maarten Timmers, Luc van Nueten, Sarah Ceyssens, Sigrid Stroobants, Manuel Morrens, Steven Staelens
Journal of Nuclear Medicine Aug 2018, 59 (8) 1267-1274; DOI: 10.2967/jnumed.117.203315
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Keywords

  • microglia
  • schizophrenia
  • 18F-PBR111
  • TSPO
  • kinetic modeling
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