Research ArticleNeurology

Longitudinal Characterization of mGluR5 Using 11C-ABP688 PET Imaging in the Q175 Mouse Model of Huntington Disease

Daniele Bertoglio, Lauren Kosten, Jeroen Verhaeghe, David Thomae, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak and Steven Staelens
Journal of Nuclear Medicine November 2018, 59 (11) 1722-1727; DOI: https://doi.org/10.2967/jnumed.118.210658

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Figures

  • FIGURE 1.
    FIGURE 1.

    Average PET images of 11C-ABP688 BPND in WT and heterozygous mice at each time point, overlaid onto MRI mouse brain template for anatomic localization. At 6 mo, n = 15 WT and 16 heterozygous mice; at 9 mo n = 15 WT and 12 heterozygous mice; at 13 mo, n = 12 WT and 15 heterozygous mice. HET = heterozygous.

  • FIGURE 2.
    FIGURE 2.

    Reduced 11C-ABP688 BPND in heterozygous mice compared with WT mice in both striatum (A) and cortex (B), as well as age-related BPND decrease in striatum. n = 15 WT and 16 heterozygous mice. *P < 0.05. **P < 0.01. ***P < 0.001. HET = heterozygous.

  • FIGURE 3.
    FIGURE 3.

    SPM results comparing 11C-ABP688 signal of 12 heterozygous and 12 WT mice. Statistical map of t values (threshold P < 0.05 [uncorrected] and cluster threshold of 100 voxels [0.8 mm3]) overlaid onto MRI mouse brain template for anatomic localization show clusters of reduced 11C-ABP688 uptake in heterozygous compared with WT mice. HET = heterozygous.

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