The study of correlation between the 18F-FDG PET-IDIF and ASL sequence imaging on hybrid PET-MR

Objectives: Positron emission tomography (PET) with 18F-FDG can provide reliable measurement of cerebral blood flow (CBF) by arterial blood sampling. Arterial spin labeling (ASL) is a magnetic resonance method for the measurement of CBF. The aim of the study was to investigate minimally invasive approaches to measure CBF by comparing simultaneous 18F-FDG PET and ASL on a hybrid PET/MR.

Methods: PET scans were obtained in 5 volunteers being evaluated for brain perfusion and ASL scans at the same time. Data on the first-pass of 18F-FDG and ASL sequence was reconstructed by the GE Healthcare work station. Regions of interest (ROIs) were drawn on the both side of frontal lobe, parietal lobe, temporal lobe and occipital lobe on the PET and CBF image with the same location, Cerebral blood flow of PET was quantified by image-derived input function (IDIF). SPSS 19 software was used for statistical analysis.

Results: The mean CBF of frontal lobe, parietal lobe, temporal lobe and occipital lobe PET-IDIF and ASL were; 51.96±5.88,52.13±7.92; 54.68±14.52, 61.54±11.69; 52.77±7.89,53.91±9.40and 59.37±12.84, 59.07±10.37 mL/100 g per minute. Blood flow estimated from the early uptake of 18F-FDG was linearly correlated with ASL-measured blood flow, with an intercept of 0.01, a slope of 0.739, and an R₂ regression coefficient of 0.606.

Conclusion: These results suggest that the first-pass uptake of 18F-FDG was possible for quantification of CBF in human. There was a correlation between the 18F-FDG PET-IDIF and ASL sequence. Research Support: NONE $$graphic_0886A0DA-6A55-4AE0-98EC-3ED8DAAA7813$$ $$graphic_8E6E2DA6-64F8-4002-91C9-D666384B046E$$