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Figures
- FIGURE 1.
Some key signaling pathways thought to be involved in CXCR4–CXCL12 signaling. On agonistic binding to CXCR4, CXCL12 is internalized and finally subjected to lysosomal degradation. Activation of CXCR4 induces β-arrestin–mediated signaling. On the basis of their sequence similarity, Gα subunits are divided into 4 families (Gαs, Gαi, Gαq, and Gα12) that regulate G protein–coupled receptor signals via different routes.
- FIGURE 2.
Maximum-intensity projections of different tumor entities undergoing 68Ga-pentixafor PET/CT: multiple myeloma, diffuse large B-cell lymphoma (DLBCL), T-cell prolymphocytic leukemia (T-PLL), adrenocortical carcinoma (ACC), and small cell lung cancer (SCLC).
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