Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans

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FIGURE 1.
Chemical structure of ¹⁸F-FTC-146.
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FIGURE 2.
WB PET maximum-intensity-projection images at different time points after ¹⁸F-FTC-146 administration in subject 7 (A) and at 30 min after ¹⁸F-FTC-146 administration in 9 subjects (B).
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FIGURE 3.
Simultaneous PET/MRI in coronal (A) and transverse (B) planes showing uptake in principal organs 30 min after ¹⁸F-FTC-146 injection in subject 10: brain (1), lungs (2), liver (3), kidneys (4), spleen (5), thyroid (6), heart (7), and pancreas (8).
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FIGURE 4.
Average (n = 9) time–activity curves for 10 principal organs. Error bars indicate ± SD. SUVs at 180 min are based on a single subject only (no error bars). Note scale difference on y-axis for urinary bladder.

TABLE 1

Subject Demographics and Administered ¹⁸F-FTC-146 Dose Data

TABLE 2

¹⁸F-FTC-146 Imaging Protocol

	Start time after tracer injection for each PET/MR scan (min)
HV no.	0	30	60	90	120	150	180	No. of WB^* PET/MR scans
1	0	43		85	122			4
2	0	35	77	100	127			5
3	0	43		101	126			4
4	0	34	69	93	123			5
5	0	38	78	104	125			5
6	0	33^†	76^†		115	132^†	172	6
7	0	31^†	74^†	102	126^†	154		6
8	0	31^†		80^†	115	136^†	172	6
9	0	32^†	73^†	100	129^†	160		6
10	0	29^†		78^†	117	139^†		5
Mean	0	34.9	74.5	93.7	122.5	144.2	172.0	5.2
SD	0	4.9	3.3	10.1	5.1	12.1	0.0	0.8

↵* Head to mid thigh scan coverage.
↵† Total-body (head to toe) scan coverage.
HV = healthy volunteer.
Actual imaging start time points (minutes after tracer administration) and number of WB PET/scans for each volunteer.

TABLE 3

¹⁸F-FTC-146 Dosimetric Data