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Meeting ReportNeurosciences Track

Initial characterization of [11C]-GSK1482160 as radioligand for P2X7 receptors

Jill Meyer, Jonathan Peters, Amanda Riley, Brian McCarthy, Minzhang Gao, Min Wang, Qi-Huang Zheng, Gary Hutchins and Paul Territo
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1793;
Jill Meyer
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Jonathan Peters
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Amanda Riley
2Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Brian McCarthy
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Minzhang Gao
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Min Wang
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Qi-Huang Zheng
1Indiana University School of Medicine Indianapolis IN United States
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Gary Hutchins
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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Paul Territo
3Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis IN United States
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    1. Skaper, S.D., P. Debetto, and P. Giusti, The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J, 2010. 24(2): p. 337-45. 2. Zhou, J., et al., Intestinal ischemia/reperfusion enhances microglial activation and induces cerebral injury and memory dysfunction in rats. Crit Care Med, 2012. 40(8): p. 2438-48. 3. Boumechache, M., et al., Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. J Biol Chem, 2009. 284(20): p. 13446-54. 4. Domercq, M., N. Vazquez-Villoldo, and C. Matute, Neurotransmitter signaling in the pathophysiology of microglia. Front Cell Neurosci, 2013. 7: p. 49. 5. Frank, M.G., et al., Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun, 2007. 21(1): p. 47-59. 6. Kreutzberg, G.W., Microglia: a sensor for pathological events in the CNS. Trends Neurosci, 1996. 19(8): p. 312-8. 7. Burnstock, G., Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov, 2008. 7(7): p. 575-90. 8. Xiang, Z., et al., Microglial morphology and its transformation after challenge by extracellular ATP in vitro. J Neurosci Res, 2006. 83(1): p. 91-101. 9. Abdi, M.H., et al., Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor. Bioorg Med Chem Lett, 2010. 20(17): p. 5080-4. 10. Gao, M., et al., Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor. Bioorg Med Chem Lett, 2015. 25(9): p. 1965-70.
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Journal of Nuclear Medicine
Vol. 57, Issue supplement 2
May 1, 2016
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Initial characterization of [11C]-GSK1482160 as radioligand for P2X7 receptors
Jill Meyer, Jonathan Peters, Amanda Riley, Brian McCarthy, Minzhang Gao, Min Wang, Qi-Huang Zheng, Gary Hutchins, Paul Territo
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1793;

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Initial characterization of [11C]-GSK1482160 as radioligand for P2X7 receptors
Jill Meyer, Jonathan Peters, Amanda Riley, Brian McCarthy, Minzhang Gao, Min Wang, Qi-Huang Zheng, Gary Hutchins, Paul Territo
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1793;
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