Utility of standardized uptake value for discrimination of bone metastasis in patients with prostate cancer by the OSCGM method using the bone segmentation algorithm.

Objectives A new SPECT/CT has improved quantitative imaging to enable the measurement of standardized uptake value (SUV) in bone scintigraphy.

Methods We evaluated sixty-three patients with prostate cancer who underwent bone SPECT/CT to detect bone metastases. SPECT/CT images including bone lesions were acquired by Symbia intevo-16 (Siemens Japan, Ltd.) 3 hours after administration of Tc-99m MDP. Maximum SUV (SUVmax) of MDP was obtained for normal thoracic and lumbar vertebrae, degenerative changes in lesions and bone metastases on SPECT/CT images reconstructed by the OSCGM method using the bone segmentation algorithm.

Results There were 21 patients with bone metastases and 42 patients with negative bone metastasis in bone scintigraphy. SUVmaxs of MDP were 7.3±1.4 (N=33) for normal thoracic vertebra, 8.1±1.8 (N=41) for normal lumbar vertebra, 16.5±8.4 (N=40) for degenerative changes, and 63.6±51.9 (N=21) for bone metastases. Maximum of the uptake in bone metastases was greater than that in the other three groups with significance (P<0.0001) by ANOVA. A receiver-operator characteristic (ROC) curve analysis between groups of degenerative lesions and metastases by bone SUVmax was 0.957 in area (p<0.0001). Sensitivity is 90.5% and Specificity is 97.5% when the threshold of SUVmax is 29.0.

Conclusions SUVmax of bone scintigraphy by the new quantitative SPECT/CT may be useful to discriminate bone metastases of prostate cancer and degenerative changes in the vertebrae.

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