Novel quantitative approaches for quantification of muscle activity using FDG-PET/CT

Objectives 1- To review the role of FDG PET/CT in assessment of muscle metabolism. 2- To propose a new methodology for quantification of muscle activity using FDG PET. Modalities currently used for estimating muscle activity and metabolism includes electromyography and MR techniques. Cine phase contrast MR can characterize the in vivo motion and mechanics of contracting skeletal muscle noninvasively but cannot measure its metabolic activity, that can be assess by electromyography and MR techniques such as spectroscopy and T2-weighted imaging. The recent development of 18F-2-deoxy-2-fuoro-D-glucose positron emission tomography/computed tomography (PET/CT), allows us to visualize and quantify in vivo metabolic activity of skeletal muscle. Although FDG-PET is well-established in oncology, cardiology, and neurology, few studies have studied the role of this imaging modality in assessment of metabolism of muscles. A novel method for quantitative analysis, developed in our lab, have the potential to improve the assessment of muscle metabolism, allowing you to quantify the overall metabolic activity of muscle tissue. In this exhibit, we are going to review the current literature on the abnormalities of muscle metabolism and the role of FDG PET and other molecular imaging techniques in assessment of in normal and abnormal states: 1-Basic concepts about physiologic muscle FDG uptake a- Application in the clinic b- Pitfalls and artifacts 2-Pathologic skeletal muscle FDG uptake: a- Primary tumors b- Metastatic tumors c- Lymphoma and multiple myeloma d- Infective and inflammatory diseases 3-Techniques of quantification of the metabolism of muscle: a- Conventional technique b- Global assessment of the whole muscle

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