In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl

Sangram Nag; Patrik Fazio; Lutz Lehmann; Georg Kettschau; Tobias Heinrich; Andrea Thiele; Marie Svedberg; Nahid Amini; Samira Leesch; Ana M. Catafau; Jonas Hannestad; Andrea Varrone; Christer Halldin

doi:10.2967/jnumed.115.161083

Research ArticleBasic Science Investigations

In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, ¹⁸F-Labeled Deuterated Fluorodeprenyl

Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M. Catafau, Jonas Hannestad, Andrea Varrone and Christer Halldin

Journal of Nuclear Medicine February 2016, 57 (2) 315-320; DOI: https://doi.org/10.2967/jnumed.115.161083

Sangram Nag

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Patrik Fazio

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Lutz Lehmann

2Bayer HealthCare AG, Global Drug Discovery, Berlin, Germany

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Georg Kettschau

2Bayer HealthCare AG, Global Drug Discovery, Berlin, Germany

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Tobias Heinrich

2Bayer HealthCare AG, Global Drug Discovery, Berlin, Germany

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Andrea Thiele

2Bayer HealthCare AG, Global Drug Discovery, Berlin, Germany

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Marie Svedberg

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Nahid Amini

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Samira Leesch

3Piramal Imaging GmbH, Berlin, Germany; and

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Ana M. Catafau

3Piramal Imaging GmbH, Berlin, Germany; and

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Jonas Hannestad

4UCB Pharma, Braine-l’Alleud, Belgium

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Andrea Varrone

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Christer Halldin

1Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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Journal of Nuclear Medicine

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February 1, 2016

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In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, ¹⁸F-Labeled Deuterated Fluorodeprenyl

Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M. Catafau, Jonas Hannestad, Andrea Varrone, Christer Halldin

Journal of Nuclear Medicine Feb 2016, 57 (2) 315-320; DOI: 10.2967/jnumed.115.161083

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In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, ¹⁸F-Labeled Deuterated Fluorodeprenyl

Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M. Catafau, Jonas Hannestad, Andrea Varrone, Christer Halldin

Journal of Nuclear Medicine Feb 2016, 57 (2) 315-320; DOI: 10.2967/jnumed.115.161083

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18F-fluorodeprenyl-D2
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monkey
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