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Research ArticleBasic Science Investigations

Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide

Géraldine Pottier, Solène Marie, Sébastien Goutal, Sylvain Auvity, Marie-Anne Peyronneau, Simon Stute, Raphaël Boisgard, Frédéric Dollé, Irène Buvat, Fabien Caillé and Nicolas Tournier
Journal of Nuclear Medicine February 2016, 57 (2) 309-314; DOI: https://doi.org/10.2967/jnumed.115.164350
Géraldine Pottier
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Solène Marie
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Sébastien Goutal
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Sylvain Auvity
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Marie-Anne Peyronneau
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Simon Stute
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Raphaël Boisgard
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Frédéric Dollé
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Irène Buvat
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Fabien Caillé
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Nicolas Tournier
1Inserm/CEA/Université Paris Sud, UMR 1023 - ERL 9218 CNRS, IMIV, Orsay, France; and
2CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, Orsay, France
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Journal of Nuclear Medicine: 57 (2)
Journal of Nuclear Medicine
Vol. 57, Issue 2
February 1, 2016
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Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide
Géraldine Pottier, Solène Marie, Sébastien Goutal, Sylvain Auvity, Marie-Anne Peyronneau, Simon Stute, Raphaël Boisgard, Frédéric Dollé, Irène Buvat, Fabien Caillé, Nicolas Tournier
Journal of Nuclear Medicine Feb 2016, 57 (2) 309-314; DOI: 10.2967/jnumed.115.164350

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Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide
Géraldine Pottier, Solène Marie, Sébastien Goutal, Sylvain Auvity, Marie-Anne Peyronneau, Simon Stute, Raphaël Boisgard, Frédéric Dollé, Irène Buvat, Fabien Caillé, Nicolas Tournier
Journal of Nuclear Medicine Feb 2016, 57 (2) 309-314; DOI: 10.2967/jnumed.115.164350
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Cited By...

  • Imaging the Activity of Efflux Transporters at the Blood-Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria
  • Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization
  • Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a {beta}-Amyloidosis Mouse Model with 11C-Metoclopramide PET
  • Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans
  • P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates
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Keywords

  • 11C-metoclopramide
  • breast cancer resistance protein
  • ABC transporter
  • blood-brain barrier
  • microdose
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