Uncertainty Quantification in Internal Dose Calculations for Seven Selected Radiopharmaceuticals

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FIGURE 1.
Compartmental model for ¹⁸F-FDG developed by MIRD Committee (14). RBCs = red blood cells.
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FIGURE 2.
Dose coefficient for ¹⁸F-FDG, according to ICRP schema (A) and to MIRD schema (B). GB = gallbladder; Ht = heart; R = red; SI = small intestine; UB = urinary bladder.
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FIGURE 3.
Dose coefficient for ^99mTc-pertechnetate (A), ^99mTc-phosphonate (B), and ^99mTc-sestamibi (C), according to ICRP schema. GB = gallbladder; Ht = heart; R = red; SI = small intestine; UB = urinary bladder.
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FIGURE 4.
Dose coefficient for ^99mTc-tetrofosmin (A) and ^99mTc-MAA (B), according to ICRP schema. GB = gallbladder; Ht = heart; R = red; SI = small intestine; UB = urinary bladder.
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FIGURE 5.
Dose coefficient for ²⁰¹Tl-chloride, according to ICRP schema. GB = gallbladder; Ht = heart; R = red; SI = small intestine; UB = urinary bladder.
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FIGURE 6.
Effective dose coefficients, according to ICRP schema.

TABLE 1

Deviations in Absorbed Dose (mGy/MBq) Calculation for Reference Voxel Phantoms and Mathematic Phantoms for ¹⁸F-FDG

	Male		Female
Target	Voxel phantom	Mathematic phantom	Voxel phantom	Mathematic phantom	Male phantom, voxel/mathematic	Female phantom, voxel/mathematic
Brain	3.5E−02	3.8E−02	3.9E−02	4.4E−02	8.5%	13.0%
Breast	9.1E−03	9.2E−03	1.2E−02	1.1E−02	1.6%	5.4%
Colon	1.2E−02	1.3E−02	1.5E−02	1.5E−02	6.7%	2.4%
Liver	2.2E−02	2.2E−02	2.7E−02	2.8E−02	0.1%	3.8%
Lungs	2.0E−02	2.0E−02	2.4E−02	2.5E−02	0.4%	3.6%
Red marrow	1.2E−02	1.2E−02	1.4E−02	1.4E−02	6.4%	4.2%
Skin	7.3E−03	8.3E−03	8.7E−03	9.7E−03	13.8%	11.6%
Stomach wall	1.2E−02	1.1E−02	1.4E−02	1.3E−02	10.7%	3.1%
Thyroid	1.0E−02	1.1E−02	1.2E−02	1.3E−02	8.6%	7.7%
Urinary bladder wall	6.9E−02	2.2E−01	1.0E−01	2.8E−01	212.8%	184.8%
Adrenals	1.3E−02	1.3E−02	1.6E−02	1.5E−02	0.4%	2.0%
Extrathoracic airways	1.0E−02	1.1E−02	1.2E−02	1.3E−02	3.9%	3.7%
Gallbladder wall	1.4E−02	1.3E−02	1.6E−02	1.5E−02	7.9%	7.6%
Heart wall	6.2E−02	6.7E−02	7.9E−02	8.9E−02	7.2%	12.2%
Kidneys	1.2E−02	1.1E−02	1.4E−02	1.4E−02	3.1%	0.9%
Muscle	9.5E−03	1.1E−02	1.1E−02	1.3E−02	14.4%	12.1%
Pancreas	1.3E−02	1.3E−02	1.4E−02	1.6E−02	2.6%	14.2%
Small intestine wall	1.3E−02	1.2E−02	1.6E−02	1.5E−02	5.2%	6.9%
Spleen	1.2E−02	1.1E−02	1.3E−02	1.4E−02	4.0%	1.8%
Thymus	1.2E−02	1.2E−02	1.6E−02	1.4E−02	3.2%	7.5%

TABLE 2

Phantom Data