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Research ArticleSupplement

The Role of Echocardiography in Heart Failure

Thomas H. Marwick
Journal of Nuclear Medicine June 2015, 56 (Supplement 4) 31S-38S; DOI: https://doi.org/10.2967/jnumed.114.150433
Thomas H. Marwick
Menzies Institute for Medical Research, Hobart, Tasmania, Australia
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  • FIGURE 1.
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    FIGURE 1.

    Calculation of LV volumes and EF from biplane Simpson’s formula using 2D echocardiography. Repeated measurement at same examination (A vs. B) shows that relatively minor (7%) difference in volume calculation translates to EF change sufficient to change a decision. LVEDV = LV end-diastolic volume; LVESV = LV end-systolic volume.

  • FIGURE 2.
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    FIGURE 2.

    Use of 3D echocardiography allows LV assumptions to be discarded. Positions of LV contours can be confirmed from 2D images (A and B) to produce 3D volume (C), and segmental evaluation can be performed (D).

  • FIGURE 3.
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    FIGURE 3.

    LV regional and global strain can be calculated from speckle-tracking of standard 2D images. Each LV segment is tracked throughout cycle to provide regional strain curve, and these are displayed in each apical view (4-chamber [A], 2-chamber [B], and long-axis [C]). Global strain is shown in polar map display (D). In this example of patient with anterior myocardial infarction, strain curves are abnormal in apical 2-chamber view and extent of infarction is illustrated in parametric display.

  • FIGURE 4.
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    FIGURE 4.

    Load dependence of diastolic evaluation from transmitral flow. In this dialysis patient, imaging during fluid overload (A) showed restrictive filling pattern, reverting to delayed relaxation (B) after development of euvolemia.

Tables

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    TABLE 1

    Measurements, Indications, and Modalities Used in Echocardiographic Evaluation of HF

    MeasurementIndicationModality
    EFClassification, risk assessment; selection for implantable cardioverter defibrillator and cardiac resynchronization therapy2D or 3D echocardiography, contrast
    Non-EF indices of functionRisk assessmentDoppler dP/dt
    Mitral regurgitant orifice areaQuantification of mitral regurgitationColor and CW Doppler
    Transmitral and annular velocitiesAssessment of diastolic function and filling pressurePulsed-wave tissue and blood-flow Doppler
    Left atrial volumePrognosis, diastolic evaluation2D or 3D echocardiography
    RV assessmentPrognosis, evaluation for assist deviceRV strain, tissue Doppler, tricuspid annular plane systolic excursion, fractional area change, etc.
    Regional functionAssessment of CADWall motion analysis, strain
    Regional timingSite of greatest maximal delayCardiac resynchronization therapy selection
    • View popup
    TABLE 2

    Situations in Which Use of E/e′ May Be Unreliable

    SituationCause
    Fusion of E and A wavesTachycardia
    Unreliable measurement of E velocitySignificant mitral regurgitation (>2+)
    Significant mitral stenosis
    Significant aortic regurgitation (>2+)
    Unreliable measurement of e′ velocitySevere mitral annular calcification
    Mitral valve repair or replacement
    Localized wall motion abnormalities
    Left bundle branch block
    Biventricular pacing
    • View popup
    TABLE 3

    Selection of the Right Tool for the Job: Imaging Characteristics of Various Tests

    ApplicationTechnical requirementTechnique
    LV hypertrophy, infiltrationHigh spatial resolutionCardiac MR
    LV synchronyHigh temporal resolutionTissue Doppler, strain
    LV volumesHigh contrast resolutionCardiac MR, contrast echocardiography
    Sequential follow-upHigh repeatabilityCardiac MR, 3D echocardiography
    Subclinical cardiomyopathySensitivity to minor changeStrain
    • View popup
    TABLE 4

    Markers of Response in Patients Undergoing Cardiac Resynchronization Therapy

    ParameterMeasureResponse at 6 mo
    ClinicalComposite“Improved”
    New York Heart Association classDecrease by at least one class
    Minnesota Living with Heart Failure questionnaire≥9-point decrease
    Exercise capacity6-min walk≥10% improvement (or any improvement if walked zero at baseline)
    LV featuresLV volume≥15% decrease
    LV EF≥5% increase
    LV massAny decrease
    Tei indexAny decrease
    Mitral valveMitral regurgitationDecrease in mitral regurgitation severity
    • View popup
    TABLE 5

    Differences Between Echocardiograms According to Parameter

    ParameterAbsolute differenceRelative difference
    ∆ Left ventricular EF8.1% ± 11.5%17% ± 30%
    ∆ Left atrial area4.0 ± 5.2 cm217% ± 23%
    ∆ Tissue Em2.1 ± 2.7 cm/s27% ± 36%
    ∆ E/e′5.0 ± 7.046% ± 64%
    • Em = mitral annular tissue diastolic velocity.

    • View popup
    TABLE 6

    Heart Failure Stages as Defined by Classification System of American College of Cardiology and American Heart Association

    StageRisk factors for HFStructural/functional heart diseaseHistory of HFClinical congestive HF
    NormalNoNoNo—
    Stage AYesNoNo—
    Stage B—YesNoNo
    Stage C1—YesNoYes
    Stage C2—YesYes—
    Stage D—YesYesYes
    • View popup
    TABLE 7

    Strengths and Weaknesses of Different Imaging Modalities

    ModalityAccessibilityPatient-friendlinessPreclinical HFAccuracyHemodynamicsRegional functionReproducibility
    Echocardiography+++++++++++
    Nuclear++−++/−+/−+
    CT++−+−++
    Cardiac MR+/−++++++++++
    • ++ = excellent; + = good; +/− = fair; − = poor.

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Journal of Nuclear Medicine: 56 (Supplement 4)
Journal of Nuclear Medicine
Vol. 56, Issue Supplement 4
June 1, 2015
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The Role of Echocardiography in Heart Failure
Thomas H. Marwick
Journal of Nuclear Medicine Jun 2015, 56 (Supplement 4) 31S-38S; DOI: 10.2967/jnumed.114.150433

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The Role of Echocardiography in Heart Failure
Thomas H. Marwick
Journal of Nuclear Medicine Jun 2015, 56 (Supplement 4) 31S-38S; DOI: 10.2967/jnumed.114.150433
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  • Article
    • Abstract
    • ECHOCARDIOGRAPHIC TOOLS FOR HF ASSESSMENT
    • SYMPTOMATIC HF
    • ASSESSMENT OF PROGNOSIS
    • SELECTION OF PATIENTS FOR DEVICE THERAPY
    • REASSESSMENT
    • EARLY DIAGNOSIS OF HF
    • CONCLUSION
    • DISCLOSURE
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Keywords

  • 2D echocardiography
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  • heart failure
  • strain
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