Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs

Objectives The primary object of the present invention is to provide a preparation method of radiation-sensitive copolymer carrier for coating nanoparticles and/or chemotherapy drugs.

Methods The method includes utilizing polymer of diselenide and 3-aminopropylpoly to react with each other to obtain diselenide block copolymer as a nano pharmaceutical carrier having hydrophilicity and hydrophobicity for forming a nanosphere by self-assembling in emulsification. The nanosphere produced by radiation-sensitive diselenide block copolymer of the present invention is stable in aqueous solution and preferable to be a potential nuclear pharmaceutical carrier for controlling collapse speed of the carrier by specific radiation.

Results Proton therapy that utilizes chemotherapy drugs made by the radiation-sensitive copolymer carrier of the present invention has decreasing proton energy in proportion with penetrated depth while the high-energy protons are hitting into the human body. The protons energy may decrease to one-third or one-fourth of primary energy while the protons are reaching to the cancer according to the penetration depth and incident energy of the protons. The incident protons having energy at 10-1000MeV will cause fission reaction of uranium-238 with certain probability while impacting the uranium-238 distributed on the cancer. FIG.1 shows the fission reaction while protons are impacting uranium-238, wherein the fission yields varies with the mass distribution. These fission products are usually unstable nuclides and subject to continuing decay reactions.

Conclusions The preparation method of the present invention that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.