Abstract
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Objectives SHINE Medical will end medical isotope shortages using its LEU-fission-based production technology.
Methods A beam-target neutron generator drives fission in a subcritical, low-enriched uranium solution, producing medical isotopes such as molybdenum-99 (Mo-99), iodine-131, and xenon-133 in large quantities. The neutrons are produced as a result of deuterium-tritium fusion reactions in a gas target. Isotope production, separation, and purification are performed on a weekly basis. The process is cost-effective and creates less waste than conventional production methods, while eliminating the use of highly enriched uranium.
Results A facility housing eight irradiation units will be built in Janesville, WI and supply up to two-thirds of U.S. demand for Mo-99. SHINE expects to receive a construction permit from the Nuclear Regulatory Commission in late 2015 and to begin construction of its manufacturing facility in 2016.
Conclusions The SHINE technology produces high-specific activity Mo-99 that is compatible with the existing supply chain. Commercial sales of medical isotopes will begin in 2018.