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Journal of Nuclear Medicine

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Meeting ReportOncology: Basic, Translational & Therapy

Optimizing and Validating Reduced PET Volume Overlap in 18F-FDG Oncology Wholebody PET/CT to Improve Speed and Patient Comfort

Jun Zhang, Katherine Binzel, Xiaoli Liu, Mona Natwa, Bin Zhang, Zhiqiang Hu, Michelle Knopp, Chi-hua Tung and Michael Knopp
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1271;
Jun Zhang
1Radiology, Ohio State University Medical Center, Columbus, OH
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Katherine Binzel
1Radiology, Ohio State University Medical Center, Columbus, OH
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Xiaoli Liu
1Radiology, Ohio State University Medical Center, Columbus, OH
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Mona Natwa
1Radiology, Ohio State University Medical Center, Columbus, OH
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Bin Zhang
2Philips Healthcare, Cleveland, OH
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Zhiqiang Hu
2Philips Healthcare, Cleveland, OH
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Michelle Knopp
1Radiology, Ohio State University Medical Center, Columbus, OH
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Chi-hua Tung
2Philips Healthcare, Cleveland, OH
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Michael Knopp
1Radiology, Ohio State University Medical Center, Columbus, OH
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Abstract

1271

Objectives To optimize and validate reducing PET acquisition volume overlap in 18F-FDG Time-of-Flight oncology wholebody PET/CT to save table time and improve patient comfort

Methods An integrated pre-clinical optimization (beagles) and clinical validation (human patients) trial was initiated to proof the feasibility of reducing PET volume overlap from established system default. In human studies, additional reduced overlap PET/CT sweeps were acquired immidiately after the default overlap standard of care imaging. Phantom evaluations were performed prior to pre-clinical studies. All imaging were acquired on a Gemini TF 64 PET/CT scanner (Philips Healthcare). Reduced PET overlaps (40%, 33%, 27%, 20%, 13% and no overlap) were investigated and compared to the system default (53%). Image quality was blindly reviewed by multiple readers using a visual scoring criteria and a quantitative SUV assessment. Patients were asked to comment on comfort

Results 20 beagle subjects were imaged. In the ongoing trial, 10 patients are currently completed and the basis this assessment. All wholebody PET exams demonstrated no impact on the visual grade with overlaps >13%. In the matched comparison, the best visual scores were found for studies using the default 53%, 40% and 27% overlaps. Reducing overlap to 27% for oncology patients saved an average of ~40% acquisition time (11min) compared to using the default overlap (18min). No significant SUV variances were found between PETs of 27% to 53% overlaps for cerebellum, lung, heart, aorta, liver, fat, muscle, bone marrow, thighs and target lesions (p>0.05), except expected variability in kidneys and bladder

Conclusions This trial demonstrates by combined pre-clinical, phantom and clinical validation that a reduction of PET volume overlap to 27% (half of the system default) can be implemented without degradation of image quality or quantification. This approach can reduce table time by 40% and additionally improves patient comfort.

Research Support Ohio Third Frontier Innovation Platform grant TECH 10-012 and 13-060

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Journal of Nuclear Medicine
Vol. 56, Issue supplement 3
May 1, 2015
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Optimizing and Validating Reduced PET Volume Overlap in 18F-FDG Oncology Wholebody PET/CT to Improve Speed and Patient Comfort
Jun Zhang, Katherine Binzel, Xiaoli Liu, Mona Natwa, Bin Zhang, Zhiqiang Hu, Michelle Knopp, Chi-hua Tung, Michael Knopp
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1271;

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Optimizing and Validating Reduced PET Volume Overlap in 18F-FDG Oncology Wholebody PET/CT to Improve Speed and Patient Comfort
Jun Zhang, Katherine Binzel, Xiaoli Liu, Mona Natwa, Bin Zhang, Zhiqiang Hu, Michelle Knopp, Chi-hua Tung, Michael Knopp
Journal of Nuclear Medicine May 2015, 56 (supplement 3) 1271;
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