Research ArticleClinical Investigations

Methodologic Considerations for Quantitative 18F-FDG PET/CT Studies of Hepatic Glucose Metabolism in Healthy Subjects

Malene Trägårdh, Niels Møller and Michael Sørensen
Journal of Nuclear Medicine September 2015, 56 (9) 1366-1371; DOI: https://doi.org/10.2967/jnumed.115.154211

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Figures

  • FIGURE 1.
    FIGURE 1.

    Time–activity curves for 18F-FDG in arterial blood (△), hepatic venous blood (○), and liver tissue (▯, insets) when 18F-FDG was administered either as bolus (A) or as constant infusion initiated by priming bolus (B). Both studies were performed during euglycemic –hyperinsulinemic clamping in same healthy human subject.

  • FIGURE 2.
    FIGURE 2.

    Paired data for extraction fractions of 18F-FDG calculated from arterial and hepatic venous blood samples (A), hepatic systemic clearance of 18F-FDG (B), and extraction fractions of 18F-FDG calculated from PET data (E*PET) (C). Different symbols represent different subjects (n = 3). Left symbol in each pair of symbols represents results from 18F-FDG administered as bolus, and right symbol in each pair of symbols represents results from 18F-FDG administered as constant infusion initiated by small priming bolus.

  • FIGURE 3.
    FIGURE 3.

    Time–activity curves for 18F-FDG in arterial blood (△), hepatic venous blood (○), and liver tissue (▯, insets) when 18F-FDG was administered as constant infusion initiated by small priming bolus during fasting (A) and during euglycemic–hyperinsulinemic clamping (B). Data were from same healthy human subject.

  • FIGURE 4.
    FIGURE 4.

    Paired data for extraction fractions of 18F-FDG calculated from arterial and hepatic venous blood samples (A), hepatic systemic clearance of 18F-FDG (B), and extraction fractions of 18F-FDG calculated from PET data (E*PET) (C). 18F-FDG was administered as constant infusion initiated by small priming bolus. Different symbols represent different subjects (n = 4). Left symbol in each pair of symbols represents results obtained during fasting, and right symbol in each pair of symbols represents results obtained during euglycemic–hyperinsulinemic clamping. (1 subject [*] underwent study only during fasting.)

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