Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum: A Study Using a High-Resolution Semiconductor PET System

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FIGURE 1.
A representative case. (A) Bilateral RN indicates areas of higher metabolism (arrowheads). (B) Coregistration with T2-weighted MR images confirmed that high ¹⁸F-FDG uptake corresponded to low-signal-intensity areas in midbrain, indicating RN (arrowheads).
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FIGURE 2.
Metabolic correlations between right RN and surface brain areas (A) and left RN and surface brain areas (B). Degree of correlation is represented by z score.
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FIGURE 3.
Scheme of possible neural networks. Width of lines represents degree of association between 2 regions. Right RN is more involved in social–emotional networks (orange regions), whereas left RN is more involved in motor function networks (blue regions). Right AC is known to be more responsible for social–emotional and alerting/arousal vigilance functions than left AC. AC = association cortex; SMC = sensorimotor cortex.

TABLE 1

Results of Voxel-by-Voxel Correlation with Right RN

↵* False discovery rate (FDR) < 0.20.
↵† FDR < 0.10.
↵‡ FDR < 0.05.
z score > 2.58, equivalent to P < 0.01 (bilateral), is shown. Talairach coordinates indicate voxels with maximum z score.
BA = Brodmann area; N/A = not available.

TABLE 2

Results of Voxel-by-Voxel Correlation with Left RN

↵* False discovery rate (FDR) < 0.20.
↵† FDR < 0.10.
↵‡ FDR < 0.05.
z score > 2.58, equivalent to P < 0.01 (bilateral), is shown. Talairach coordinates indicate voxels with maximum z score.
BA = Brodmann area; N/A = not available.