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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

Radiation Dosimetry of the Fibrin-Binding Probe 64Cu-FBP8 and Its Feasibility for PET Imaging of Deep Vein Thrombosis and Pulmonary Embolism in Rats

Francesco Blasi, Bruno L. Oliveira, Tyson A. Rietz, Nicholas J. Rotile, Helen Day, Pratap C. Naha, David P. Cormode, David Izquierdo-Garcia, Ciprian Catana and Peter Caravan
Journal of Nuclear Medicine July 2015, 56 (7) 1088-1093; DOI: https://doi.org/10.2967/jnumed.115.157982
Francesco Blasi
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Bruno L. Oliveira
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Tyson A. Rietz
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Nicholas J. Rotile
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Helen Day
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Pratap C. Naha
2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and
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David P. Cormode
2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and
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David Izquierdo-Garcia
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Ciprian Catana
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
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Peter Caravan
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
3Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts
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Journal of Nuclear Medicine: 56 (7)
Journal of Nuclear Medicine
Vol. 56, Issue 7
July 1, 2015
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Radiation Dosimetry of the Fibrin-Binding Probe 64Cu-FBP8 and Its Feasibility for PET Imaging of Deep Vein Thrombosis and Pulmonary Embolism in Rats
Francesco Blasi, Bruno L. Oliveira, Tyson A. Rietz, Nicholas J. Rotile, Helen Day, Pratap C. Naha, David P. Cormode, David Izquierdo-Garcia, Ciprian Catana, Peter Caravan
Journal of Nuclear Medicine Jul 2015, 56 (7) 1088-1093; DOI: 10.2967/jnumed.115.157982

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Radiation Dosimetry of the Fibrin-Binding Probe 64Cu-FBP8 and Its Feasibility for PET Imaging of Deep Vein Thrombosis and Pulmonary Embolism in Rats
Francesco Blasi, Bruno L. Oliveira, Tyson A. Rietz, Nicholas J. Rotile, Helen Day, Pratap C. Naha, David P. Cormode, David Izquierdo-Garcia, Ciprian Catana, Peter Caravan
Journal of Nuclear Medicine Jul 2015, 56 (7) 1088-1093; DOI: 10.2967/jnumed.115.157982
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Cited By...

  • Dosimetry of [64Cu]FBP8: a fibrin-binding PET probe
  • Detection and Characterization of Thrombosis in Humans using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance
  • In Vivo Molecular Characterization of Abdominal Aortic Aneurysms Using Fibrin-Specific Magnetic Resonance Imaging
  • 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi
  • Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats
  • Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of 111In- and 68Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats
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More in this TOC Section

  • How Sensitive Is the Upper Gastrointestinal Tract to 90Y Radioembolization? A Histologic and Dosimetric Analysis in a Porcine Model
  • 11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis
  • Counting Rate Characteristics and Image Distortion in Preclinical PET Imaging During Radiopharmaceutical Therapy
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Keywords

  • thrombosis
  • PET imaging
  • fibrin
  • DVT-PE
  • dosimetry
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