Development of a Widely Usable Amino Acid Tracer: 76Br-α-Methyl-Phenylalanine for Tumor PET Imaging

Hirofumi Hanaoka; Yasuhiro Ohshima; Yurika Suzuki; Aiko Yamaguchi; Shigeki Watanabe; Tomoya Uehara; Shushi Nagamori; Yoshikatsu Kanai; Noriko S. Ishioka; Yoshito Tsushima; Keigo Endo; Yasushi Arano

doi:10.2967/jnumed.114.152215

Research ArticleBasic Science Investigations

Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging

Hirofumi Hanaoka, Yasuhiro Ohshima, Yurika Suzuki, Aiko Yamaguchi, Shigeki Watanabe, Tomoya Uehara, Shushi Nagamori, Yoshikatsu Kanai, Noriko S. Ishioka, Yoshito Tsushima, Keigo Endo and Yasushi Arano

Journal of Nuclear Medicine May 2015, 56 (5) 791-797; DOI: https://doi.org/10.2967/jnumed.114.152215

Hirofumi Hanaoka

1Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, Maebashi, Japan

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Science, Chiba University, Chiba, Japan

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Yasuhiro Ohshima

3Medical Radioisotope Application Group, Life Science and Biotechnology Division, Quantum Beam Science Center, Research Department of Nuclear Science, Japan Atomic Energy Agency, Takasaki, Japan

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Yurika Suzuki

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Science, Chiba University, Chiba, Japan

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Aiko Yamaguchi

1Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, Maebashi, Japan

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Shigeki Watanabe

3Medical Radioisotope Application Group, Life Science and Biotechnology Division, Quantum Beam Science Center, Research Department of Nuclear Science, Japan Atomic Energy Agency, Takasaki, Japan

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Tomoya Uehara

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Science, Chiba University, Chiba, Japan

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Shushi Nagamori

4Division of Biosystem Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan; and

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Yoshikatsu Kanai

4Division of Biosystem Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Japan; and

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Noriko S. Ishioka

3Medical Radioisotope Application Group, Life Science and Biotechnology Division, Quantum Beam Science Center, Research Department of Nuclear Science, Japan Atomic Energy Agency, Takasaki, Japan

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Yoshito Tsushima

5Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Keigo Endo

5Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Yasushi Arano

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Science, Chiba University, Chiba, Japan

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Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging

Hirofumi Hanaoka, Yasuhiro Ohshima, Yurika Suzuki, Aiko Yamaguchi, Shigeki Watanabe, Tomoya Uehara, Shushi Nagamori, Yoshikatsu Kanai, Noriko S. Ishioka, Yoshito Tsushima, Keigo Endo, Yasushi Arano

Journal of Nuclear Medicine May 2015, 56 (5) 791-797; DOI: 10.2967/jnumed.114.152215

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Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging

Hirofumi Hanaoka, Yasuhiro Ohshima, Yurika Suzuki, Aiko Yamaguchi, Shigeki Watanabe, Tomoya Uehara, Shushi Nagamori, Yoshikatsu Kanai, Noriko S. Ishioka, Yoshito Tsushima, Keigo Endo, Yasushi Arano

Journal of Nuclear Medicine May 2015, 56 (5) 791-797; DOI: 10.2967/jnumed.114.152215

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Keywords

76Br
α-methyl-l-phenylalanine
tumor imaging
PET

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Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging

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