Article Figures & Data
Figures
- FIGURE 1.
Representative images of subjects with 11C-PiB–different ratings in static, BP, sn-SUVR – 1, and sn-BP images. Case 1 is an 80-y-old man: mild cognitive impairment, SUVR-equivocal, and BP-positive. Case 2 is a 72-y-old woman: AD, SUVR- and BP-equivocal. Case 3 is an 83-y-old man: AD, SUVR-negative and BP-positive. Case 4 is a 74-y-old woman, undiagnosed, SUVR-negative and BP-equivocal. SUVR, BP, sn-SUVR – 1, and sn-BP images are demonstrated in order from left to right. Arrows in cases 1 and 3 show 11C-PiB–positive regions, and those in case 4 show 11C-PiB–equivocal portions. In case 2, extended cortical uptake is suspected.
- FIGURE 2.
Correlation between mean gray matter SUVR and BPND in all subjects.
- FIGURE 3.
Distribution and values of mean gray matter uptake among 11C-PiB–negative, 11C-PiB–equivocal, and 11C-PiB–positive groups (SUVR [A], BPND [B]).
- FIGURE 4.
Ratio of gray matter 11C-PiB uptake to white matter retention in SUVR (A), BPND (B), and DVR (C) among 11C-PiB–negative, 11C-PiB–equivocal, and 11C-PiB–positive groups.
Tables
Static/BP Negative Equivocal Positive Negative 26 2 4 Equivocal 0 2 8 Positive 0 0 43 - TABLE 2
Comparison of Visual White Matter Uptake Between Static and BP Images Among 3 Static Rating Groups
Group Negative Equivocal Positive Static > BP 23 9 34 Static = BP 9 1 9 Static < BP 0 0 0 Visual assessment Quantification Age Sex Diagnosis MMSE Static sn-SUVR − 1 BP sn-BP White matter SUVR BPND 74 Female UD 23 N N E E Static = BP 1.01 0.39 54 Male UD 29 N N E E Static = BP 0.98 0.26 83 Male AD 25 N N P P Static > BP 1.07 0.06 66 Male UD 28 N N P P Static > BP 1.17 0.04 62 Male MCI — N N P P Static > BP 1.02 0.2 84 Female AD 21 N N P P Static > BP 1.11 0.04 72 Female AD 22 E E E E Static = BP 1.35 0.87 75 Female FTLD 19 E E E E Static > BP 1.05 0.08 77 Female UD 24 E E P P Static > BP 1.37 0.52 81 Male AD 24 E E P P Static > BP 1.85 0.62 67 Male AD 21 E E P P Static > BP 1.69 0.44 80 Male MCI 26 E E P P Static > BP 1.50 0.06 83 Male MCI 27 E E P P Static = BP 1.76 0.48 75 Male PD 20 E E P P Static > BP 1.38 0.07 79 Male MCI 25 E E P P Static > BP 1.61 0.25 MMSE = mini mental state examination; sn = spatially normalized; UD = undiagnosed; N = negative; E = equivocal; P = positive; MCI = mild cognitive impairment; FTLD = frontotemporal lobar degeneration; PD = Parkinson disease.
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