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Journal of Nuclear Medicine

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Research ArticleClinical Investigations

Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease

Christine A. Parker, Eugenii A. Rabiner, Roger N. Gunn, Graham Searle, Laurent Martarello, Robert A. Comley, Maria Davy, Alan A. Wilson, Sylvain Houle, Romina Mizrahi, Marc Laruelle and Vincent J. Cunningham
Journal of Nuclear Medicine December 2015, 56 (12) 1901-1909; DOI: https://doi.org/10.2967/jnumed.115.162743
Christine A. Parker
1GlaxoSmithKline, Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
2Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom
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Eugenii A. Rabiner
3Imanova Ltd., Imperial College London, London, United Kingdom
4Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, United Kingdom
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Roger N. Gunn
2Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom
3Imanova Ltd., Imperial College London, London, United Kingdom
5Department of Engineering Science, University of Oxford, Oxford, United Kingdom
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Graham Searle
2Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom
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Laurent Martarello
6AbbVie, Translational Imaging, Integrated Science and Technology, North Chicago, Illinois
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Robert A. Comley
7Roche Pharmaceutical Research and Early Development, Basel, Switzerland
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Maria Davy
8GlaxoSmithKline, Neuroscience Therapy Area Unit, Stevenage, United Kingdom
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Alan A. Wilson
9Research Imaging Centre, CAMH, and Department of Psychiatry, University of Toronto, Toronto, Canada
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Sylvain Houle
9Research Imaging Centre, CAMH, and Department of Psychiatry, University of Toronto, Toronto, Canada
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Romina Mizrahi
9Research Imaging Centre, CAMH, and Department of Psychiatry, University of Toronto, Toronto, Canada
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Marc Laruelle
10Intra-Cellular Therapies Inc., New York, New York; and
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Vincent J. Cunningham
11School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
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Journal of Nuclear Medicine: 56 (12)
Journal of Nuclear Medicine
Vol. 56, Issue 12
December 1, 2015
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Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease
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Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease
Christine A. Parker, Eugenii A. Rabiner, Roger N. Gunn, Graham Searle, Laurent Martarello, Robert A. Comley, Maria Davy, Alan A. Wilson, Sylvain Houle, Romina Mizrahi, Marc Laruelle, Vincent J. Cunningham
Journal of Nuclear Medicine Dec 2015, 56 (12) 1901-1909; DOI: 10.2967/jnumed.115.162743

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Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease
Christine A. Parker, Eugenii A. Rabiner, Roger N. Gunn, Graham Searle, Laurent Martarello, Robert A. Comley, Maria Davy, Alan A. Wilson, Sylvain Houle, Romina Mizrahi, Marc Laruelle, Vincent J. Cunningham
Journal of Nuclear Medicine Dec 2015, 56 (12) 1901-1909; DOI: 10.2967/jnumed.115.162743
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Keywords

  • 5HT6
  • human kinetic modeling
  • 11C-GSK215083
  • SB742457
  • Alzheimer’s disease
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