Article Figures & Data
Figures
- FIGURE 1.
18F-FDG PET scan patterns displayed by Neurostat 3D-SSP for focal-onset dementias. Lat = lateral; LBD = Lewy body dementia; Lt = left; Med = medial; Rt = right.
Tables
Subgroup selected by diagnostic marker Sex (no. of patients) Age at PET scan (y) Identification Description No. of patients Men Women Median Minimum–Maximum 1 11C-PiB imaging of AD 51 27 24 65 53–81 2 18F-FDG imaging of AD 49 22 27 65 53–81 3 Clinical AD 24 13 11 69 56–81 4 Clinical PPA-L (AD variant) 19 7 12 67 53–78 5 Clinical PPA-G 16 12 4 71 48–80 6 Clinical PPA-S 13 8 5 64 54–77 7 Clinical CBS 14 6 8 64 57–73 8 (pooled 3 and 4) Clinical AD and PPA-L 43 20 23 69 53–81 9 (pooled 5–7) Clinical PPA-G, PPA-S, and CBS 43 26 17 66 48–80 10 Entire cohort 94 52 42 68 37–81 - TABLE 2
AD Prevalence Rates in Cohort Subgroups, as Indicated by Clinical and Imaging Diagnostic Markers
Selected subgroup AD prevalence rate in subgroup AD prevalence rate in cohort Identification Description 11C-PiB 18F-FDG Clinical 11C-PiB 18F-FDG Clinical 1 11C-PiB imaging for AD 1.00 0.86 0.75 0.54 0.47 0.40 2 18F-FDG imaging for AD 0.90 1.00 0.73 0.47 0.52 0.38 3 Clinical AD 0.88 0.75 1.00 0.22 0.19 0.26 4 Clinical PPA-L (AD variant) 0.89 0.95 1.00 0.18 0.19 0.20 5 Clinical PPA-G 0.31 0.25 0.00 0.05 0.04 0.00 6 Clinical PPA-S 0.08 0.00 0.00 0.01 0.00 0.00 7 Clinical CBS 0.36 0.50 0.00 0.05 0.07 0.00 8 Clinical AD and PPA-L 0.88 0.84 1.00 0.40 0.38 0.46 9 Clinical PPA-G, PPA-S, and CBS 0.26 0.26 0.00 0.12 0.12 0.00 10 Entire cohort 0.54 0.52 0.46 0.54 0.52 0.46 Name Acronym Formula Positive predictive value PPV TP/(TP + FP) Negative predictive value NPV TN/(TN + FN) Positive likelihood ratio PLR [TP/(TP + FN)]/[FP/(FP + TN)] Negative likelihood ratio NLR [FN/(TP + FN)]/[TN/(FP + TN)] Sensitivity or rate of TP results TPR TP/(TP + FN) Specificity or rate of TN results TNR TN/(TN + FP) Conventional accuracy CA (TP + TN)/(TP + FP + FN + TN) Balanced accuracy BA [TP/(TP + FN) + TN/(TN + FP)]/2 Discordance of accuracies DA |CA − BA| All measures except DA were expressed in terms of numbers of TP, FP, TN, and FN results.
Subgroup Identification Description PPV NPV PLR NLR TPR ± SE TNR ± SE CA ± SE BA ± DA 3 AD 0.88 0.88 ± 0.07 0.50 ± 0.38 4 PPA-L (AD variant) 0.11 0.11 ± 0.07 0.50 ± 0.40 5 PPA-G 0.69 0.69 ± 0.12 0.50 ± 0.19 6 PPA-S 0.92 0.92 ± 0.07 0.50 ± 0.42 7 CBS 0.64 0.64 ± 0.13 0.50 ± 0.14 8 AD and PPA-L 0.88 0.11 0.92 1.12 0.55 ± 0.08 0.40 ± 0.22 0.53 ± 0.08 0.48 ± 0.06 9 PPA-G, PPA-S, and CBS 0.74 0.74 ± 0.07 0.50 ± 0.24 10 Entire cohort 0.88 0.57 5.90 0.63 0.41 ± 0.07 0.93 ± 0.04 0.65 ± 0.05 0.67 ± 0.02 PPV = positive predictive value; NPV = negative predictive value; PLR = positive likelihood ratio; NLR = negative likelihood ratio; TPR = rate of TP results; TNR = rate of TN results; CA = conventional accuracy; BA = balanced accuracy; DA = discordance of accuracies.
Subgroup Identification Description PPV NPV PLR NLR TPR ± SE TNR ± SE CA ± SE BA ± DA 3 AD 0.96 0.37 2.38 0.27 0.81 ± 0.08 0.75 ± 0.20 0.80 ± 0.08 0.78 ± 0.05 4 PPA-L (AD variant) 0.94 0.81 1.91 0.09 0.96 ± 0.02 0.50 ± 0.35 0.91 ± 0.07 0.73 ± 0.18 5 PPA-G 0.92 0.96 11.0 0.10 0.90 ± 0.09 0.95 ± 0.04 0.94 ± 0.06 0.93 ± 0.03 6 PPA-S 0.92 1.10 0.92 ± 0.05 0.85 ± 0.10 0.46 ± 0.39 7 CBS 0.68 0.97 3.90 0.06 0.95 ± 0.04 0.75 ± 0.14 0.82 ± 0.10 0.85 ± 0.03 8 AD and PPA-L 0.95 0.42 2.71 0.19 0.88 ± 0.05 0.65 ± 0.21 0.85 ± 0.05 0.76 ± 0.09 9 PPA-G, PPA-S, and CBS 0.72 0.94 8.10 0.18 0.84 ± 0.11 0.88 ± 0.06 0.87 ± 0.05 0.86 ± 0.02 10 Entire cohort 0.86 0.83 5.21 0.18 0.85 ± 0.05 0.83 ± 0.06 0.84 ± 0.04 0.84 ± 0.00 PPV = positive predictive value; NPV = negative predictive value; PLR = positive likelihood ratio; NLR = negative likelihood ratio; TPR = rate of TP results; TNR = rate of TN results; CA = conventional accuracy; BA = balanced accuracy; DA = discordance of accuracies.
