Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
Meeting ReportInstrumentation & Data Analysis

High resolution PET imaging of tau using an MR-based information theoretic anatomical prior

Joyita Dutta, Quanzheng Li, Keith Johnson, Xuping Zhu and Georges El Fakhri
Journal of Nuclear Medicine May 2014, 55 (supplement 1) 642;
Joyita Dutta
1Radiology, Massachusetts General Hospital, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Quanzheng Li
1Radiology, Massachusetts General Hospital, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keith Johnson
1Radiology, Massachusetts General Hospital, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xuping Zhu
1Radiology, Massachusetts General Hospital, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georges El Fakhri
1Radiology, Massachusetts General Hospital, Boston, MA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

642

Objectives PET Imaging of tau tangles in the brain is highly promising for monitoring the progression of Alzheimer’s disease and chronic traumatic encephalopathies. However, partial volume effects associated with the limited PET spatial resolution pose a challenge to quantitation. We developed an MR-based prior for partial volume correction in PET and applied it to [18F]T807 imaging in 10 subjects.

Methods Our technique is based on 1) deconvolution of PET data with the spatially variant point spread function (PSF) of the scanner measured in the image space and 2) an MR-based information theoretic framework that minimizes the joint entropy between PET and T1MPRAGE MR. The PSF was measured with 0.5 mm diameter 18F point sources placed at different radial and axial locations in the scanner bore. The proposed joint entropy prior obviates the need for MR segmentation. We validate our approach in a Hoffman phantom and evaluate its performance in 10 normal subjects imaged for 20 min with [18F]T807 by quantifying grey to white matter SUV ratios. Correlations of the conventional and corrected PET images with the MMSE scores of the subjects are computed to further evaluate performance.

Results Joint entropy based deconvolution successfully recovered edges and structural details in the PET images. In the Hoffman phantom, the mean grey-to-white SUV ratio increased from 3.0 to 3.3 (ground truth 4.0). There was a prominent reduction in the standard deviation of the SUV by 19% in the grey matter and 37% in the white matter. In [18F]T807 studies, the correlation coefficient of the MMSE scores with the SUVRs for the whole brain, the temporal lobe, the inferior temporal gyrus, the hippocampus, and the parahippocampal gyrus improved by 32%, 21%, 3%, 4%, and 13% respectively.

Conclusions Accurate measurement of the PET PSF and MR-based priors led to significantly enhanced image contrast and reduction of variability. This translated into improved correlation of [18F]T807 SUVRs with neuropsychological test scores, making this approach promising for quantitative imaging of tauopathies.

Previous
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 55, Issue supplement 1
May 2014
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
High resolution PET imaging of tau using an MR-based information theoretic anatomical prior
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
High resolution PET imaging of tau using an MR-based information theoretic anatomical prior
Joyita Dutta, Quanzheng Li, Keith Johnson, Xuping Zhu, Georges El Fakhri
Journal of Nuclear Medicine May 2014, 55 (supplement 1) 642;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
High resolution PET imaging of tau using an MR-based information theoretic anatomical prior
Joyita Dutta, Quanzheng Li, Keith Johnson, Xuping Zhu, Georges El Fakhri
Journal of Nuclear Medicine May 2014, 55 (supplement 1) 642;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Instrumentation & Data Analysis

  • Phantom for evaluation of dedicated nuclear medicine breast imaging systems
  • MRC-SPECT-DF: An MR-Compatible SPECT System with A Dual-FOV Collimator Design for Microscopic SPECT Imaging
  • Dynamic range is acceptable for myocardial blood flow quantification with the Scintron LSO 3D-PET system
Show more Instrumentation & Data Analysis

Image Generation: PET/MR

  • Comparison of MRI-guided attenuation correction strategies in PET/MRI
  • Real-time 3D MR respiratory motion acquisition for simultaneous PET/MR imaging
  • Joint estimation of activity and attenuation in TOF-PET/MR using constrained Gaussian mixture models
Show more Image Generation: PET/MR

Similar Articles

SNMMI

© 2022 Journal of Nuclear Medicine

Powered by HighWire