Efficacy evaluation of 188Re-human serum albumin microsphere in hepatoma model

Objectives The aim of this study was to investigate the efficacy evaluation of intraarterially administrated 188Re-human serum albumin microsphere (188Re-HSAM) in the GP7TB hepatoma rat model.

Methods Male F344 rats were intrahepatic inoculation with GP7TB 1 mm3 cubes. These studies were performed on rat at 26 d after tumor inoculation. The efficacy of 188Re-HSAM was performed by a single-dose treatment in GP7TB hepatoma rat via intraarterial route. Rats were checked for survival every day until death. The body weight was measured once a week.

Results In efficacy study, the median survival time for the rat, which received normal saline was 80 d. The median survival times for the mice treated with 10 mCi, 4.8 mCi and 2.9 mCi of 188Re-HSAM were 130 d (P = 0.003), 90.25 d (P = 0.035) and 83.5 d (P = 0.617), respectively. The increase in life span of 10 mCi, 4.8 mCi and 2.9 mCi of 188Re-HSAM were 62.5%, 12.8% and 4.4%, respectively.

Conclusions The therapeutic studies of 188Re-HSAM demonstrated better survival time and therapeutic efficacy for rat with increased dose in the GP7TB hepatoma model. These results suggested that intraarterial administration of 188Re-HSAM could provide a benefit and promising strategy for delivery of radiotherapeutics in oncology applications.