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Research ArticleClinical Investigations

Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood–Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

Anand K. Deo, Soo Borson, Jeanne M. Link, Karen Domino, Janet F. Eary, Ban Ke, Todd L. Richards, David A. Mankoff, Satoshi Minoshima, Finbarr O’Sullivan, Sara Eyal, Peng Hsiao, Ken Maravilla and Jashvant D. Unadkat
Journal of Nuclear Medicine July 2014, 55 (7) 1106-1111; DOI: https://doi.org/10.2967/jnumed.113.130161
Anand K. Deo
1Department of Pharmaceutics, University of Washington, Seattle, Washington
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Soo Borson
2Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington
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Jeanne M. Link
3Department of Radiology, University of Washington, Seattle, Washington
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Karen Domino
4Department of Anesthesiology, University of Washington, Seattle, Washington; and
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Janet F. Eary
3Department of Radiology, University of Washington, Seattle, Washington
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Ban Ke
1Department of Pharmaceutics, University of Washington, Seattle, Washington
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Todd L. Richards
3Department of Radiology, University of Washington, Seattle, Washington
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David A. Mankoff
3Department of Radiology, University of Washington, Seattle, Washington
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Satoshi Minoshima
3Department of Radiology, University of Washington, Seattle, Washington
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Finbarr O’Sullivan
3Department of Radiology, University of Washington, Seattle, Washington
5Department of Statistics, University College Cork, Cork, Ireland
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Sara Eyal
1Department of Pharmaceutics, University of Washington, Seattle, Washington
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Peng Hsiao
1Department of Pharmaceutics, University of Washington, Seattle, Washington
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Ken Maravilla
3Department of Radiology, University of Washington, Seattle, Washington
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Jashvant D. Unadkat
1Department of Pharmaceutics, University of Washington, Seattle, Washington
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Article Information

vol. 55 no. 7 1106-1111
DOI 
https://doi.org/10.2967/jnumed.113.130161
PubMed 
24842892

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 31, 2013
  • Accepted for publication March 17, 2014
  • Published online July 1, 2014.

Article Versions

  • previous version (May 19, 2014 - 05:27).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Anand K. Deo1,
  2. Soo Borson2,
  3. Jeanne M. Link3,
  4. Karen Domino4,
  5. Janet F. Eary3,
  6. Ban Ke1,
  7. Todd L. Richards3,
  8. David A. Mankoff3,
  9. Satoshi Minoshima3,
  10. Finbarr O’Sullivan3,5,
  11. Sara Eyal1,
  12. Peng Hsiao1,
  13. Ken Maravilla3 and
  14. Jashvant D. Unadkat1
  1. 1Department of Pharmaceutics, University of Washington, Seattle, Washington
  2. 2Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington
  3. 3Department of Radiology, University of Washington, Seattle, Washington
  4. 4Department of Anesthesiology, University of Washington, Seattle, Washington; and
  5. 5Department of Statistics, University College Cork, Cork, Ireland
  1. For correspondence or reprints contact: Jashvant D. Unadkat, Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195. E-mail: jash{at}u.washington.edu
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Journal of Nuclear Medicine: 55 (7)
Journal of Nuclear Medicine
Vol. 55, Issue 7
July 1, 2014
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Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood–Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease
Anand K. Deo, Soo Borson, Jeanne M. Link, Karen Domino, Janet F. Eary, Ban Ke, Todd L. Richards, David A. Mankoff, Satoshi Minoshima, Finbarr O’Sullivan, Sara Eyal, Peng Hsiao, Ken Maravilla, Jashvant D. Unadkat
Journal of Nuclear Medicine Jul 2014, 55 (7) 1106-1111; DOI: 10.2967/jnumed.113.130161

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Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood–Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease
Anand K. Deo, Soo Borson, Jeanne M. Link, Karen Domino, Janet F. Eary, Ban Ke, Todd L. Richards, David A. Mankoff, Satoshi Minoshima, Finbarr O’Sullivan, Sara Eyal, Peng Hsiao, Ken Maravilla, Jashvant D. Unadkat
Journal of Nuclear Medicine Jul 2014, 55 (7) 1106-1111; DOI: 10.2967/jnumed.113.130161
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Keywords

  • Alzheimer’s disease
  • blood–brain barrier
  • P-glycoprotein activity
  • PET imaging
  • relative extraction ratio
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