Article Figures & Data
Figures
- FIGURE 1.
Illustration of regional binary masks warped from reference brain to ADNI image volume with nonrigid deformation field. Regions include cerebellum (1); midbrain (2); pons (3); occipital lobe (4); cingulate cortex (5); sublobar region (6) including corpus callosum, caudate, putamen, globus pallidus, thalamus, and right and left frontal lobes (7, 8); right and left parietal lobes (9, 10); and right and left temporal lobes (11, 12).
- FIGURE 2.
Comparison between 18F-FDG vectors at baseline and follow-up in 2 subjects. Lower figure shows subject with low correlation, and upper figure shows subject with high correlation.
- FIGURE 3.
Comparison between normal (black dashed line) and MCI (red solid line) subjects with respect to their rFTC(t).
- FIGURE 4.
Changes in rFTC, MMSE, FAQ, and ADAS_cog values with age in MCI subject who has large decline in cognitive scores.
- FIGURE 5.
Changes in rFTC, MMSE, FAQ, and ADAS_cog values with age in MCI subject who has moderate decline in cognitive scores.
Tables
Characteristic MCI Normal No. of subjects 27 24 Female 13 11 Male 14 13 Average age at baseline 74.6 ± 7.2 74.53 ± 5.7 APOE-ε4 17 6 Baseline ADAS_cog 11 ± 4.7 6 ± 2.6 Baseline FAQ 3.2 ± 2.8 0.1 ± 0.6 Baseline MMSE 27.4 ± 1.4 29.2 ± 0.9 Model Fixed effect Estimate P 1 ADAS_cog time:MCI 1.6 0.0001 rFTC time:MCI −0.02 0.0001 MMSE time:MCI −0.82 0.0002 FAQ time:MCI 2.5 0.0001 2 ADAS_cog time:APOE 1.14 0.001 rFTC time:APOE −0.014 0.008 MMSE time:APOE −0.44 0.007 FAQ time:APOE 1.32 0.0001 Both models were performed for rFTC(t), MMSE(t), ADAS-cog(t), and FAQ(t) as outcome variables. With the first model (time:MCI), we see how changes in these variables over time differed between MCI and normal subjects. Second model (time:APOE) shows how changes in these variables over time differed between the group with positive APOE-ε4 and control group.
Method A Method B Variable Median P Median P ADAS-cog/rFTC 0.5 0.011 0.81 0.0005 MMSE/rFTC 0.5 0.0039 0.64 0.00004 FAQ/rFTC 0.6 0.0016 0.4 0.0002 Wilcoxon rank-sum tests of Spearman rank correlation between rFTC and each of 3 cognitive tests (method A) and correlation between residuals of linear regressions on rFTC(t) and 3 cognitive tests (method B).
