Research ArticleBasic Science Investigations

Elevated 18F-FDG Levels in Blood and Organs After Angiotensin II Receptor Blocker Administration: Experiment in Mice Administered Telmisartan

Yan Zhao, Songji Zhao, Yuji Kuge and Nagara Tamaki
Journal of Nuclear Medicine August 2013, 54 (8) 1384-1388; DOI: https://doi.org/10.2967/jnumed.111.100248

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Figures

  • FIGURE 1.
    FIGURE 1.

    Graphs showing positive correlations between 18F-FDG and BUN levels (r = 0.48, P < 0.01) (A) and between 18F-FDG and creatinine levels (r = 0.61, P < 0.01) (B).

  • FIGURE 2.
    FIGURE 2.

    (A) In mice given 20 wk of telmisartan treatment, 18F-FDG accumulation levels in blood, muscle, liver, and spleen were significantly higher in moderate-dose group and high-dose group than in control group. (B) After 3-wk treatment cessation, 18F-FDG levels in blood and organs were same as those in control group. *P < 0.0083 for Bonferroni post hoc test vs. control group.

  • FIGURE 3.
    FIGURE 3.

    Autoradiographic images of 18F-FDG in kidney sections. Red arrows indicate medulla, and blue arrows indicate cortex. In mice before start of telmisartan treatment (*1), 18F-FDG markedly accumulated in inner part of medulla. During telmisartan treatment, intensive accumulation of 18F-FDG in inner part of medulla markedly decreased to be as low as that in cortex. Two or 3 wk after treatment cessation (*2), gradual recovery of 18F-FDG accumulation was observed at inner part of medulla. w = weeks.

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