Article Figures & Data
Figures
- FIGURE 1.
Synthesis of 11C-BU99008.
- FIGURE 2.
Summed PET images in porcine brain. Transverse (left), coronal (middle), and sagittal (right) images and tissue time–activity curves for 11C-BU99008 for selected ROIs in porcine brain (scale bar expresses percentage injected dose per liter; lines represent 1TC model fits). (A) Baseline 11C-BU99008 scan. (B) 11C-BU99008 scan after administration of BU224 (5 mg/kg).
- FIGURE 3.
Fraction of unchanged 11C-BU99008 present in plasma.
- FIGURE 4.
VT estimates for selected ROIs using 1TC model for baseline 11C-BU99008 scans (n = 3; mean ± SD) and scans after administration of BU224 (0.01 mg/kg, n = 1, and 5.00 mg/kg, n = 1).
- FIGURE 5.
Plot of PET data obtained from 1TC model to estimate occupancy of I2 binding sites after administrations of BU224 at 0.01 and 5.00 mg/kg.
- FIGURE 6.
In vitro affinities of imidazoline I2 binding site ligands.
- FIGURE 7.
Graph showing correlation of baseline 11C-BU99008 VT values against autoradiographic distribution of I2 ligands using 3H-2-BFI (triangles) and 3H-idazoxan (squares) in rat whole brain.
Tables
- TABLE 1
VT Estimates for Selected ROIs Using 1TC Model for Baseline 11C-BU99008 Scans and Scans After Administration of BU224
VT Cerebellum Frontal cortex Hippocampus Striatum Thalamus Baseline (mL/cm3)* 26.6 ± 4.1 29.3 ± 4.7 36.2 ± 7.9 43.6 ± 7.9 49.7 ± 11.0 After BU224 administration 0.01 mg/kg† 17.0 18.3 20.6 25.4 28.3 5.00 mg/kg† 8.1 8.8 10.5 10.6 10.9
Supplemental Data
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