Myoview and Sestamibi redistribution, stress once - image twice protocol improves detection of ischemia in addition to improving patient throughput and reducing patient radiation to 3.75 mSv

Objectives Measurement of serial stress-stress redistribution of Tc-99m compounds, Myoview and Sestamibi has demonstrated an enhanced detection of ischemia as presented at the 2011 SNM and HPS meetings. Automation of this technique to reduce imaging time, improve diagnostic accuracy and reduce radiation levels to 3.75 mSv for ALL patients is investigated in this study.

Methods Two hundred patients undergoing SPECT MPI imaging at three hospitals in a Major Metropolitan Community were studied using the previously verified FHRWW protocol, using an automated software (copyright and licensure pending) program to reduce imaging time, radiation dosage and determine diagnostic accuracy.

Results Automated comparisons of stress-stress imaging for the measurement of Myoview and Sestamibi redistribution produced identical results to that obtained using outstanding technician driven processing without the problem of technician variability and fatigue factors. SPECT Image acquisition time was reduced from 25 minutes to 2 minutes 40 seconds for each acquisition. Total patient table time was reduced from 50 minutes to less than 5 minutes 30 seconds. Patient radiation was reduced from 10-15 mSv to 3.75 mSv.

Conclusions The automated software system is adaptable to all current modern SPECT cameras and reduced patient table time, improved patient throughput, reduced patient and health care worker radiation exposure and maintained the accuracy of measuring the redistribution of Myoview and Sestamibi previously presented at the 2011 SNM meetings.

Research Support O.I