Article Figures & Data
Figures
- FIGURE 1.
Structure of NTA and ASMA ligands. Ellipse encloses dangling carboxyl group, and asterisk indicates asymmetric carbon.
- FIGURE 2.
Preparation of 2 diastereomers of 99mTc(CO)3(l-ASMA).
- FIGURE 3.
HPLC of 99mTc(CO)3(l-ASMA): labeling mixture (A), before injection (B), in urine at 15 min after injection (C), and ultraviolet trace (254 nm) of Re(CO)3(l-ASMA) (D). AU = absorbance units.
- FIGURE 4.
Biodistribution of 99mTc(CO)3(rac-ASMA) and 131I-OIH in normal rats at 10 min (A) and 60 min (B) after injection and in rats with renal pedicle ligation at 60 min after injection (C), expressed as %ID per organ, blood, and urine.
Tables
- TABLE 1
Biodistribution (%ID) of 99mTc(CO)3(ASMA) and 131I-OIH in Normal (Group A) and Renal Pedicle–Ligated (Group B) Rats
Parameter Blood Liver Stomach Intestine Kidney Urine % urinary 99mTc/131I 10 min, group A 99mTc-rac-ASMA* 5.2 ± 1.7 2.5 ± 0.3 0.2 ± 0.0 0.5 ± 0.1 6.7 ± 1.0 51.3 ± 6.2 106 ± 6 131I-OIH 6.7 ± 1.9 3.7 ± 0.6 0.3 ± 0.1 1.7 ± 0.3 6.5 ± 0.7 48.3 ± 4.9 P 0.0711 0.0178 0.0041 0.1104 99mTc-l-ASMA† 4.7 ± 0.9 3.7 ± 1.2 0.2 ± 0.0 0.8 ± 0.2 4.3 ± 2.2 51.1 ± 7.3 100 ± 3 131I-OIH 5.1 ± 1.0 2.9 ± 0.3 0.3 ± 0.1 1.5 ± 0.3 4.0 ± 1.8 50.9 ± 6.0 P 0.0704 0.4576 0.0792 0.9003 60 min, group A 99mTc-rac-ASMA‡ 0.2 ± 0.0 0.2 ± 0.1 0.0 ± 0.0 0.4 ± 0.1 0.2 ± 0.1 94.4 ± 1.0 106 ± 0 131I-OIH 0.7 ± 0.1 0.7 ± 0.1 0.2 ± 0.0 1.3 ± 0.3 0.3 ± 0.1 89.1 ± 0.9 P 0.0002 0.0050 0.0413 0.0008 99mTc-l-ASMA* 0.3 ± 0.1 0.3 ± 0.0 0.0 ± 0.0 0.5 ± 0.2 0.7 ± 0.3 95.1 ± 4.1 107 ± 2 131I-OIH 0.8 ± 0.1 0.6 ± 0.2 0.1 ± 0.1 1.3 ± 0.3 0.7 ± 0.3 88.8 ± 2.7 P 0.0034 0.0061 0.0001 0.0007 60 min, group B 99mTc-rac-ASMA* 17.9 ± 1.1 6.2 ± 0.6 0.7 ± 0.2 4.4 ± 0.6 0.6 ± 0.2 — — 131I-OIH 16.7 ± 1.3 7.9 ± 0.5 0.5 ± 0.2 8.9 ± 2.2 0.5 ± 0.2 — P 0.0175 0.0323 0.0189
