A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β−-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Cristina Müller; Konstantin Zhernosekov; Ulli Köster; Karl Johnston; Holger Dorrer; Alexander Hohn; Nico T. van der Walt; Andreas Türler; Roger Schibli

doi:10.2967/jnumed.112.107540

Research ArticleBasic Science Investigations

A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β⁻-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Cristina Müller, Konstantin Zhernosekov, Ulli Köster, Karl Johnston, Holger Dorrer, Alexander Hohn, Nico T. van der Walt, Andreas Türler and Roger Schibli

Journal of Nuclear Medicine December 2012, 53 (12) 1951-1959; DOI: https://doi.org/10.2967/jnumed.112.107540

Cristina Müller

1Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland

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Konstantin Zhernosekov

1Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland

2Laboratory of Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, Villigen-PSI, Switzerland

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Ulli Köster

3Institut Laue-Langevin, Grenoble, France

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Karl Johnston

4Physics Department, ISOLDE/CERN, Geneva, Switzerland

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Holger Dorrer

2Laboratory of Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, Villigen-PSI, Switzerland

5Department of Chemistry and Biochemistry, Laboratory of Radiochemistry and Environmental Chemistry, University of Bern, Bern, Switzerland

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Alexander Hohn

1Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland

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Nico T. van der Walt

6Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville, South Africa; and

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Andreas Türler

2Laboratory of Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, Villigen-PSI, Switzerland

5Department of Chemistry and Biochemistry, Laboratory of Radiochemistry and Environmental Chemistry, University of Bern, Bern, Switzerland

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Roger Schibli

1Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland

7Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland

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Journal of Nuclear Medicine

Vol. 53, Issue 12

December 1, 2012

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A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β⁻-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Cristina Müller, Konstantin Zhernosekov, Ulli Köster, Karl Johnston, Holger Dorrer, Alexander Hohn, Nico T. van der Walt, Andreas Türler, Roger Schibli

Journal of Nuclear Medicine Dec 2012, 53 (12) 1951-1959; DOI: 10.2967/jnumed.112.107540

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A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β⁻-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Cristina Müller, Konstantin Zhernosekov, Ulli Köster, Karl Johnston, Holger Dorrer, Alexander Hohn, Nico T. van der Walt, Andreas Türler, Roger Schibli

Journal of Nuclear Medicine Dec 2012, 53 (12) 1951-1959; DOI: 10.2967/jnumed.112.107540

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Keywords

terbium radioisotopes
folate receptor targeting
SPECT
PET
radionuclide therapy

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A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β⁻-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

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