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- FIGURE 1.
In vitro cytotoxic effects of magnetic-core (black bars) and magnetic-fluorescence (white bars) nanoparticles. Twenty micrograms of each type were used to treat Hep3B hepatocarcinoma cell line, and time-dependent (A) and dose-dependent (B) MTT assay was performed. Significant reduction of cell viability was observed 1 d after treatment with magnetic-core nanoparticles, compared with magnetic-fluorescence nanoparticles. Cell viability gradually decreased until 10-μg concentration of magnetic-core nanoparticles was reached. *P < 0.05. **P < 0.0005.
- FIGURE 2.
Dynamic small-animal PET and biodistribution study. (A) Dynamic PET images (coronal, sagittal, and axial views) showing exclusive accumulation of 68Ga-labeled magnetic-core nanoparticles in liver, with radioactivity remaining until 60 min. (B) Biodistribution profile for mice injected with 68Ga-labeled magnetic-core (black bars) and magnetic-fluorescence (white bars) nanoparticles. Data are expressed as percentage of injected dose per gram of tissue.
- FIGURE 3.
Genotoxic effects of magnetic-core and magnetic-fluorescence nanoparticles on Hep3B cells and liver tissues. Real-time PCR array was conducted using total RNA samples isolated from 3 groups (untreated [white bars], magnetic-core–treated [hatched bars], and magnetic-fluorescence–treated [black bars]) of Hep3B cells and in vivo liver tissue. (A) Genes significantly affected by magnetic-core nanoparticles when both types of nanoparticles were used to directly treat Hep3B cells. (B) Genes showing significantly enhanced expression in magnetic-core–treated in vivo liver samples when both types of nanoparticles were injected into mice via tail vein.
- FIGURE 4.
Graph showing relatively strong correlation between untreated and magnetic-fluorescence (MF)–treated groups in vitro (A) and in vivo (B).
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