Abstract
2403
Objectives There are various radiopharmaceuticals used for brain flow studies. This research compares and contrasts the kits utilized in brain flow studies in Nuclear Medicine.
Methods Four different radioactive pharmaceuticals may be used for brain flow studies: 99mTcO4, 99mTcDTPA, 99mTcECD, and 99mTcHMPAO. These various pharmaceuticals will be compared based on a variety of factors. Comparisons include body distribution, cost, excretion, expiration, dosage, method of injection, radiation dose to other organs, passage via the blood brain barrier, QC tests and imaging.
Results At Froedtert 99mTcO4 is commonly used for brain flow studies. This method is preferential to the other methods based on the comparison criterion. When a Mo99 generator is on hand, it is easier to obtain bulk technetium rather than prepare a kit. It is also cheaper than the three kits as shown in the table below. Furthermore, bulk technetium or a generator has a longer expiration time than the three other kits. A comparison study with 99mTcDTPA was performed to view the difference in images obtained between 99mTcO4 and 99mTcDTPA.
Conclusions The use of 99mTcO4 has proven to be the most cost effective and efficient for brain flow imaging. This is proven by a comparative analysis of 99mTcO4, 99mTcDTPA, 99mTcECD, and 99mTcHMPAO. Froedtert continues to use 30 mCi of 99mTcO4 for brain flow studies with confidence in a clear positive or negative study.
Research Support Kevin J. Donohoe, MD et al. “Society of Nuclear Medicine Procedure Guideline for Brain Death Scintigraphy.” 25 February 2003. www.interactive.snm.org; Ceretec Kit for Preparation Exametazime. Medi-Physics, Inc., Amersham Healthcare. Arlington Heights, IL; Pharmalucence Kit for Preparation Pentetate. Pharmalucence, Inc. Bedford, MA; Neurolite. Kit for Preparation Bicisate. Du Pont Radiopharmaceutical Division. Billerica, MA
Radiopharmaceutical Cost Difference
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