Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Meeting ReportNeurosciences: Neurology

Longitudinal study of changes in FDDNP-PET and neuropsychological scores

Moses Wilks, Praba Siddarth, Linda Ercoli, Vladimir Kepe, Gary Small, Jorge Barrio and Sung-Cheng Huang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1266;
Moses Wilks
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Praba Siddarth
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linda Ercoli
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vladimir Kepe
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gary Small
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jorge Barrio
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sung-Cheng Huang
1UCLA School of Medicine, Los Angeles, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

1266

Objectives To predict changes in neuropsychological test scores from longitudinal distribution volume ratio (DVR) images of FDDNP-PET data.

Methods 14 subjects (6 Control, 8 MCI) underwent a dynamic FDDNP scan for up to 125 minutes. T1-weighted MPRage MRIs were performed for each subject. FDDNP scans were repeated for all subjects two years later. At both visits, subjects were given a battery of neuropsychological exams. These tests included MMSE, Boston Naming, WAIS-III Block Design, and WAIS-III Digit Symbol tests. Logan analysis was performed to create DVR images for all subjects for both FDDNP scans. Subject MRIs were normalized to a common space through of structural warping. This normalization was applied to rigidly aligned DVR images to bring them into the common space. VOIs drawn in the common space were used to extract average DVR values from 9 cortical regions in the normalized PET images. Multiple linear regression was used to model changes in psychological test scores as a function of changes in regional DVR values. An exhaustive search of models using three or fewer predictor regions was performed to find the best models.

Results Block Design scores best correlated with data from frontal lobe, lower temporal, and posterior cingulate regions (r2=.87, p<0.001) that are related to planning and execution, memory, and integration, respectively. Boston naming test scores were related to upper parietal, lower temporal, and medial temporal regions (r2=.65, p=0.011), corresponding to the use of association cortices and memory. Digit symbol scores correlated with data in occipital-parietal, posterior cingulate, and lower temporal regions (r2=.67, p=0.015), which are used in association, integration, and memory. MMSE correlated with data from upper parietal and posterior temporal regions (r2=.80, p<0.001). In all cases, increase in DVR was inversely correlated with test performance.

Conclusions Changes in regional FDDNP-DVR data can be used to predict changes in specific mental tasks associated with the corresponding regions.

Research Support NIH grant P01-AG025483

Back to top

In this issue

Journal of Nuclear Medicine
Vol. 52, Issue supplement 1
May 2011
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Longitudinal study of changes in FDDNP-PET and neuropsychological scores
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Longitudinal study of changes in FDDNP-PET and neuropsychological scores
Moses Wilks, Praba Siddarth, Linda Ercoli, Vladimir Kepe, Gary Small, Jorge Barrio, Sung-Cheng Huang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1266;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Longitudinal study of changes in FDDNP-PET and neuropsychological scores
Moses Wilks, Praba Siddarth, Linda Ercoli, Vladimir Kepe, Gary Small, Jorge Barrio, Sung-Cheng Huang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1266;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Neurosciences: Neurology

  • Comparison of cerebral grey matter atrophy and hypometabolism in posterior cortical atrophy using voxel-based morphometry in MRI and FDG-PET
  • Unexpected activation of Wernicke’s area in tinnitus patients
  • Precuneus amyloid burden is associated with decreased bilateral frontal activation and default network suppression in healthy adults
Show more Neurosciences: Neurology

Neurology Posters

  • A new diagnostic marker for differentiating multi centric gliomas from multiple intracranial diffuse large B-cell lymphomas on 18F-FDG PET images
  • Technetium-99m pentavalent dimercaptosuccinic acid (99mTc-DMSA-V) brain SPECT/CT and Karnofsky performance score predict survival in patients with glioma
  • IDH1 mutation is associated with low FDG upatke in cerebral gliomas associated with low FDG uptake in cerebral gliomas.
Show more Neurology Posters

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire