FDG uptake in pineal body tumor: Significant correlation with proliferative activity measured by Ki-67 labeling index

Objectives In this study, correlations of FDG uptakes with the proliferative activity measured by the Ki-67 index are evaluated in cases with pineal body tumor.

Methods Seven patients with pienal body tumor were enrolled in this study. FDG-PET were performed within two weeks before biopsy or treatment of the lesions in all cases. As a semiquantitative analysis, standardized uptake values (SUV) of the primary tumors were measured. Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of FDG.

Results In the pathological analysis after surgery, 2 astrocytoma, 2 pineal parenchymal tumor, 1 metastasis, 1 germinoma and 1 pineocytoma were confirmed. In all 7 cases, FDG uptake were noted SUVmax=7-22.1). In 6 cases, correlation with FDG uptake and MIB1 index wereperformed and significant correlation was noted (r=0.867, p=0.0254)

Conclusions Significant correlation of FDG uptake with proliferative activity in pienal tumor was confirmed and it is suggested that FDG PET may be useful in the decision of therapeutic plan