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Meeting ReportNeurosciences: Basic Science

Metabolic and behavioral responses to acute and chronic morphine

Joseph Carrion, Amanda Talan, Stergiani Agorastos, Alexandra Aarons, Sandra Scherrer, Stephen Dewey, Krishna Patel, Christina Veith and Wynne Schiffer
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1199;
Joseph Carrion
2Department of Molecular Biology, City College of New York, New York, NY
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Amanda Talan
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Stergiani Agorastos
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Alexandra Aarons
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Sandra Scherrer
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Stephen Dewey
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Krishna Patel
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Christina Veith
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Wynne Schiffer
1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY
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Abstract

1199

Objectives Rodents administered sub-chronic escalating doses of morphine exhibit decreases in relative glucose metabolism in the frontal cortex, thalamus, and cerebellum. These region-specific changes are consistent with human behaviors associated with drug use and addiction. The role of regional differences in brain metabolism between acute and chronic drug use to disease progression and treatment has not been fully considered, if at all. Using 18FDG and Micro Positron Emission Tomography (MicroPET), we show that morphine administered acutely in rodents has an opposite effect on brain metabolism compared to rodents undergoing chronic morphine exposure.

Methods Two groups of adult male rats received serial FDG PET scan. Group 1 received a single dose of morphine (10mg/kg) 15min prior to FDG. Group 2 was treated with escalating doses of morphine for 14 days (10mg/kg to 42.5mg/kg). FDG scans occurred baseline and after 1, 7, and 21 days of withdrawal. Behavioral measures were obtained during and after morphine treatment.

Results Acutely, morphine significantly increased FDG uptake in the striatum and decreased uptake in the frontal cortex and cerebellum (see Figure). Sub-chronic treatment resulted in persistent decreases in FDG uptake in both cortical (frontal, parietal, temporal cortices) and subcortical structures (deep cerebellar nuclei, striatum, thalamus). Behavioral measures of withdrawal severity correlated with regional changes in FDG uptake in these regions.

Conclusions Acute morphine treatment causes regionally specific changes in FDG uptake that parallel the lasting decrements observed after sub-chronic treatment.

Research Support Supported by DOD PR02620 and NIH R01-DA0252

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Journal of Nuclear Medicine
Vol. 52, Issue supplement 1
May 2011
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Metabolic and behavioral responses to acute and chronic morphine
Joseph Carrion, Amanda Talan, Stergiani Agorastos, Alexandra Aarons, Sandra Scherrer, Stephen Dewey, Krishna Patel, Christina Veith, Wynne Schiffer
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1199;

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Metabolic and behavioral responses to acute and chronic morphine
Joseph Carrion, Amanda Talan, Stergiani Agorastos, Alexandra Aarons, Sandra Scherrer, Stephen Dewey, Krishna Patel, Christina Veith, Wynne Schiffer
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1199;
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