Research ArticleBasic Science Investigations

Reproducibility of Serial Left Ventricle Perfusion, Volume, and Ejection Fraction Measurements Using Multiplexed Multipinhole SPECT in Healthy Rats and Rats After Myocardial Infarction

Jared H. Strydhorst, Frans H. Leenen, Terrence D. Ruddy and R. Glenn Wells
Journal of Nuclear Medicine August 2011, 52 (8) 1285-1292; DOI: https://doi.org/10.2967/jnumed.111.088658

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  • TABLE 1

    Reproducibility of Cardiac Perfusion Measurements in Healthy Rats

    ParameterMean perfusionReproducibility
    Interscan
     Least variable segment86.8%2.4% (segment 8)
     Most variable segment80.6%3.6% (segment 3)
     Average84.3%2.8%
    Intersubject
     Least variable segment87.9%3.2% (segment 7)
     Most variable segment86.8%5.0% (segment 8)
     Average84.3%4.0%
  • TABLE 2

    Reproducibility of Cardiac Perfusion Measurements in Infarcted Rats

    ParameterMean perfusionReproducibility
    Interscan
     Least variable segment21.4%3.1% (segment 16)
     Most variable segment76.5%7.1% (segment 6)
     Average63.1%5.3%
    Intersubject
     Least variable segment82.7%5.0% (segment 8)
     Most variable segment58.5%26.9% (segment 11)
     Average63.1%14.4%
  • TABLE 3

    Average Combined z Scores for 5 Scans of 8 Infarcted Rats

    RatCombined z score
    1−88 ± 22
    2−115 ± 7
    3−102 ± 8
    4−84 ± 8
    5−54 ± 5
    6−143 ± 5
    7−84 ± 8
    8−82 ± 4
  • TABLE 4

    Reproducibility of Functional Measurements in Healthy Rats

    ParameterMeanReproducibility
    Interscan (n = 8)
     Ejection fraction57%3.1% ± 1.6%
     Diastolic volume470 mm320 ± 7 mm3
     Systolic volume203 mm313 ± 6 mm3
    Intersubject (n = 5)
     Ejection fraction57%3.3% ± 1.5%
     Diastolic volume470 mm344 ± 16 mm3
     Systolic volume204 mm324 ± 5 mm3

    • Volumes are after normalization. Because interscan data are normalized to average weight of each rat, and intersubject data are normalized to average weight of all rats for each scan, the means differ slightly.

  • TABLE 5

    Reproducibility of Functional Measurements in Infarcted Rats

    ParameterMeanReproducibility
    Interscan (n = 8)
     Ejection fraction45%3.6% ± 2.4%
     Diastolic volume834 mm349 ± 12 mm3
     Systolic volume462 mm337 ± 17 mm3
    Intersubject (n = 5)
     Ejection fraction45%8.1% ± 2.4%
     Diastolic volume832 mm3126 ± 20 mm3
     Systolic volume462 mm3121 ± 14 mm3

    • Volumes are after normalization. Because interscan data are normalized to average weight of each rat, and intersubject data are normalized to average weight of all rats for each scan, the means differ slightly.

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