Research ArticleBasic Science Investigations

Using the NEMA NU 4 PET Image Quality Phantom in Multipinhole Small-Animal SPECT

Anita A. Harteveld, Antoi P.W. Meeuwis, Jonathan A. Disselhorst, Cornelis H. Slump, Wim J.G. Oyen, Otto C. Boerman and Eric P. Visser
Journal of Nuclear Medicine October 2011, 52 (10) 1646-1653; DOI: https://doi.org/10.2967/jnumed.110.087114

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    RCrod (A) and %STDRC (B) for 99mTc-filled rods of 1-, 2-, and 3-mm diameter as function of number of iterations showing effect of postreconstruction spatial filtering. Mean activity was 9.4 MBq with 1-h WB acquisition time. All reconstructions were performed without scatter correction. FWHM = full width at half maximum.

  • FIGURE 2.
    FIGURE 2.

    RCrod (A) and %STDRC (B) for 99mTc-filled rods of 1-, 2-, and 3-mm diameter as function of number of iterations showing effect of scatter correction (SC). Mean activity was 9.4 MBq with 1-h WB acquisition time. All reconstructions were performed without postreconstruction filtering.

  • FIGURE 3.
    FIGURE 3.

    %STDunif for 99mTc-filled uniform phantom region as function of number of iterations, with different postreconstruction filter settings. Scatter correction did not change %STDunif; accordingly, only results without scatter correction are shown. Mean activity was 9.4 MBq with 1-h WB acquisition time. FWHM = full width at half maximum.

  • FIGURE 4.
    FIGURE 4.

    SOR for cold water and air compartments as function of number of iterations, with and without scatter correction (SC). Postreconstruction spatial filtering did not change %STDunif; accordingly, only results without filtering are shown. Mean activity was 9.4 MBq with 1-h WB acquisition time.

  • FIGURE 5.
    FIGURE 5.

    %STDunif as function of average phantom activity for time frames of 1-h WB acquisition time: unfiltered (A) and postreconstruction gaussian filter of 1.0 mm (B) and 1.5 mm in full width at half maximum (C).

  • FIGURE 6.
    FIGURE 6.

    (A and B) Transverse images of NU 4 IQ phantom showing, from left to right, filled rods, uniform phantom region, and region containing cold water and air compartments. Images were obtained using 9.4 MBq, scatter correction, no filter, and 6 iterations (A) or 9.4 MBq, scatter correction, postreconstruction gaussian filter of 1.0 mm in full width at half maximum, and 6 iterations (B). (C and D) Maximum-intensity-projection images of 99mTc-hydroxymethylene diphosphonate bone scans of mouse. WB acquisition time was 1 h in all cases. Images were obtained using 9.4 MBq, scatter correction, no filter, and 6 iterations (C) or 9.4 MBq, scatter correction, postreconstruction gaussian filter of 1.0 mm in full width at half maximum, and 6 iterations (D).

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