Initial experience with FDG PET-CT in patients with clinically suspected oncogenic osteomalacia (OGOM)

Objectives OGOM is a rare entity. It is difficult to localize the tumor causing osteomalacia. The present study was aimed to evaluate the role of PET-CT in patients with high degree of clinical suspicion of OGOM.

Methods 15 patients (male/female: 9/6; mean age 40 years, range 26-55 years) with high degree of clinical suspicion of OGOM underwent whole body (head to toe) PET-CT scans. All patients were thoroughly investigated biochemically and radiologically. PET-CT findings were correlated with postoperative histopathological result/ clinical follow-up.

Results 10 patients had abnormal PET-CT study and in 5 patients PET-CT was normal (no localization). All 10 patients with abnormal PET-CT underwent surgery. All these patients except 1 showed normalization of biochemical parameters. All 5 patients in whom PET-CT was normal, there was worsening of symptoms. Detailed results are given in Table.

Conclusions PET-CT has definite role in localizing tumor in patients with suspicion of OGOM. In addition, PET-CT has advantage of whole body screening in one procedure

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Results

NL- not localized, PNS- paranasal sinus, HPC- hemangiopericytoma, SND- surgery not done, PMT- phosphaturic mesenchymal tumor, P- positive, N- Normal, R- recovered.