This Month in JNM

Imaging neuroinflammation: Winkeler and colleagues provide an overview of current methods for imaging neurologic inflammation, with emphasis on radioisotopic techniques.
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Assessing PET/CT reports: Graham reviews quality and significance factors relative to data generated for the National Oncologic PET Registry and previews an article in this issue of JNM on PET/CT reports from this database.
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PET and dopamine cell transplantation: Ma and colleagues expand on previous work to report on long-term clinical outcomes, including those assessed by ¹⁸F-FDOPA PET imaging, in patients with Parkinson disease treated with embryonic dopamine cell implantation.
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Automated PET/CT amplitude gating: Chang and colleagues present an automated respiratory amplitude gating technique for implementation on current whole-body PET/CT scanners that would obviate breath-holding without increased radiation exposure.
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¹⁸F-FDG avidity in lymphoma: Weiler-Sagie and colleagues report on the results of ¹⁸F-FDG PET/CT in a large cohort of patients newly diagnosed with Hodgkin disease and non-Hodgkin lymphoma, with special attention to tracer avidity in distinct subtypes of lymphoma.
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SPECT/CT prostate tumor grading: Seo and colleagues describe phantom studies evaluating a method using ¹¹¹In-capromab pendetide SPECT/CT for in vivo quantification of antibody uptake and accurate staging of prostate tumors.
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¹⁸F-FMISO in head and neck cancer: Wang and colleagues use pharmacokinetic analysis of ¹⁸F-FMISO dynamic PET to delineate regional tumor hypoxia and investigate relationships among various quantifiable and functional factors in patients with head and neck cancer.
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CZT nuclear cardiac imaging: Herzog and colleagues establish optimal scan times for nuclear myocardial perfusion imaging on an ultrafast cardiac γ-camera using novel cadmium-zinc-telluride solid-state detector technology.
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Imaging cirrhotic portal hypertension: Gao and colleagues investigate the diagnostic utility and clinical significance of transsplenic portal scintigraphy in evaluating cirrhotic portal hypertension and compensatory circulation.
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¹³N PET in COPD: Vidal Melo and colleagues report on the use of ¹³N-saline PET for assessment of spatial heterogeneity of lung perfusion as an early biomarker of pulmonary vascular involvement in patients with chronic obstructive pulmonary disease.
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PET in radiotherapy planning: Troost and colleagues provide an educational overview of the current role and future potential of PET for selection and delineation of radiotherapy target volumes and for biologic characterizations of tumor entity.
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COMKAT software for image quantification: Fang and colleagues describe an integrated, open-source software package with multiple functions for incorporating tracer pharmacokinetic analysis into molecular imaging research.
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⁶⁴Cu-C-ANF PET in atherosclerosis: Liu and colleagues explore the potential of a radiolabeled C-type atrial natriuretic peptide factor for vascular targeting in PET imaging of developing atherosclerotic plaquelike lesions.
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Imaging RAGE: Tekabe and colleagues determine whether expression of the receptor for advanced glycation end products can be detected in atherosclerosis using SPECT and describe the potential for this technique in identifying early accelerated disease in diabetes mellitus.
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Cancer-targeted multimodal imaging: Hwang and colleagues report on development of and animal studies with an aptamer-conjugated nanoparticle for concurrent in vivo fluorescence, radionuclide, and MR imaging.
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Genetic PET in breast cancer: Thakur and colleagues investigate the utility of a radiolabeled peptide analog for PET discrimination of breast cancer in a transgenic mouse model and discuss possible applications in early imaging of primary and metastatic disease.
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PET and cannabinoid receptors: Terry and colleagues evaluate a promising analog with high brain uptake, high specific binding, and reduced uptake in bone for PET imaging of cannabinoid receptors in studies with monkeys and healthy humans.
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Abl kinase PET: Doubrovin and colleagues assess the feasibility of a PET-based molecular imaging method for direct visualization of Abl kinase expression and protein kinase inhibitor treatment.
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PET and photodynamic therapy: Fei and colleagues explore the use of ¹¹C-choline PET to monitor very early tumor response to photodynamic therapy in mouse models of human prostate cancer.
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Biodistribution and dosimetry of ¹¹C-(R) PK11195: Kumar and colleagues derive biodistribution data and radiation dose estimates for this PET tracer, which facilitates noninvasive imaging of microglial activation in several pediatric and adult neurologic disorders.
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Dosimetry of ¹⁸F-PBR06 in humans: Fujimura and colleagues estimate radiation absorbed doses for this PET tracer that measures the translocator protein 18 kDa, a biomarker for inflammation in the human brain.
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Rituximab and ⁹⁰Y-ibritumomab dosimetry: Shen and colleagues determine whether the therapeutic effects of ⁹⁰Y-ibritumomab in relapsed B-cell non-Hodgkin lymphoma might be enhanced by a full course of rituximab followed by single dose of ⁹⁰Y-ibritumomab.
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PET and PET/CT reports: Coleman and colleagues use data from the National Oncologic PET Registry database to identify core elements for inclusion in oncologic PET reports and evaluate a sample subset of these reports.
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ON THE COVER

Clinical benefit and graft viability have been found to be sustained for up to 4 y after transplantation of human embryonic dopaminergic tissue for advanced Parkinson disease. Changes in imaging measures, as shown by these maps of mean striatal ¹⁸F-FDOPA uptake in transplant recipients, were associated with clinical outcome over the entire posttransplantation time course.

See page 11.