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Meeting ReportNeurosciences: Neurology

Dominant hemisphere's vulnerability may explain chronic fatigue after mild traumatic brain injury (mTBI)

Naoya Hattori, Megan Swan Foster, Gary Stobbe, Jay Uomoto, Satoshi Minoshima, David Djang, Ruben Krishnananthan and David Lewis
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 369;
Naoya Hattori
1University of Washington, Seattle, WA
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Megan Swan Foster
2Seattle Pacific University, Seattle, WA
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Gary Stobbe
1University of Washington, Seattle, WA
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Jay Uomoto
3VA Puget Sound Health Care System, Seattle, WA
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Satoshi Minoshima
1University of Washington, Seattle, WA
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David Djang
4Seattle Nuclear Medicine, Seattle, WA
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Ruben Krishnananthan
1University of Washington, Seattle, WA
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David Lewis
1University of Washington, Seattle, WA
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Abstract

369

Objectives Patients with mild traumatic brain injury (mTBI) may present with impaired neuropsychological function. The study objective was to investigate its correlation with resting rCBF.

Methods Fifteen right-handed mTBI patients (12 F, 3 M, 45±11 years) with chronic fatigue underwent Tc-99m ECD brain perfusion SPECT at rest and also the PASAT (Paced Auditory Serial Addition Task) consisting of 4 sessions. Patients with reproducible low scores were considered as impaired neuropsychological function. SPECT images were analyzed using 3D-SSP. Comparison with normal database of 15 age- and sex-matched volunteers provided individual z-score maps allowing visualization of regional perfusion abnormality. The results were summarized in 10 cortical regions and were statistically investigated.

Results Total scores of 4 PASAT sessions for the normal controls were 147 ± 24, while patients with mTBI were 158 ± 12 (p = n.s) for preserved (9/15), and 74 ± 38 (p < 0.0001) for impaired (6/15) neuropsychological function. Z-score maps and statistical analyses observed laterality towards hypoperfusion (higher z-score values) in the left hemisphere, particularly in patients with preserved neuropsychological function (1.32 ± 0.35 vs. 1.59 ± 0.26, p < 0.05).

Conclusions Patients with mTBI showed hypoperfusion particularly in the dominant (left) hemisphere, which may explain fatigue symptoms even without abnormal neuropsychological test. Patients with impaired function did not demonstrate laterality, probably due to globally reduced rCBF.

  • © 2009 by Society of Nuclear Medicine
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Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
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Dominant hemisphere's vulnerability may explain chronic fatigue after mild traumatic brain injury (mTBI)
Naoya Hattori, Megan Swan Foster, Gary Stobbe, Jay Uomoto, Satoshi Minoshima, David Djang, Ruben Krishnananthan, David Lewis
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 369;

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Dominant hemisphere's vulnerability may explain chronic fatigue after mild traumatic brain injury (mTBI)
Naoya Hattori, Megan Swan Foster, Gary Stobbe, Jay Uomoto, Satoshi Minoshima, David Djang, Ruben Krishnananthan, David Lewis
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 369;
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