Abstract
1693
Objectives Lymphoscintigraphy and sentinel node biopsy has become a standard method for detection of axillary lymph node metastasis in breast cancer patients, but the standard radiopharmaceutical was not prepared. About detection of axillary lymph node metastasis by lymphoscintigraphy and sentinel node biopsy in breast cancer patient, we compared the results of Tc-99m Tin-colloid and Tc-99m Phytate by subareolar injection.
Methods This study included 462 breast cancer patients who were performed operation during 2001-2008. Four hundred twelve patients was injected 0.8 ml of Tc-99m Tin-colloid (37-185 MBq) by subareolar injection. Fifty patients was injected 0.8 ml of Tc-99m Phytate (37-185 MBq). Lymphoscintigraphy was performed in supine position and sentinel node localization was performed by hand-held gamma probe in operation.
Results Among 412 patients by Tc-99m Tin-colloid, 374 cases (90.8%) localized the sentinel node by lymphoscintigraphy, 364 cases (88.3%) localized by gamma probe. Among 50 patients by Tc-99m Phytate, 48 cases (96.0%) localized by lymphoscintigraphy, 47 cases (94.0%) localized by gamma probe. Detection rate by lymphoscintigraphy and gamma probe was superior for Tc-99m Phytate compared to that with Tc-99m Tin-colloid, with a statistically significant difference. (p<0.05, p<0.05)
Conclusions Tc-99m Phytate is a better choice for localization of sentinel node than Tc-99m Tin-colloid in breast cancer patients.
- © 2009 by Society of Nuclear Medicine