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Meeting ReportOncology - Basic: Therapy, Metrics and Intervention

The effectiveness of SPECT/CT in hepatic arterial Tc-99m MAA scan (MAAS) planning prior to hepatic Y-90 microsphere therapy (YT)

Sherif Heiba, Manli Jiang, J Weintraub, F. S. Nowakowski, P. Stangl, Anondo Stangl, Scott Nowakowski, Edward Kim, Karin Knesaurek, Zhuangyu Zhang and Josef Machac
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1663;
Sherif Heiba
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Manli Jiang
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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J Weintraub, F. S. Nowakowski, P. Stangl
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Anondo Stangl
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Scott Nowakowski
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Edward Kim
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Karin Knesaurek
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Zhuangyu Zhang
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Josef Machac
1Mount Sinai School of Medicine, Nuclear Medicine & Interventional Radiology Divisions, New York, NY
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Abstract

1663

Objectives MAAS is utilized to assess proper infusion catheter positioning & absence of abdominal extrahepatic shunting (ES) prior to YT. To this end, accuracy & certainty of planar & SPECT were compared with SPECT/CT MAAS findings on same patients.

Methods 133 MAAS were performed with planar & SPECT/CT prior to YT. Planar, SPECT, & SPECT/CT were separately reviewed by 2 observers for hepatic regional distribution (HRD) pattern (right, left lobes, segmental or all), & presence/location of ES. The confidence in each assessment was categorized as certain or uncertain. Most patients had prior liver therapy (36 partial resection, 74 chemoembolization, & 16 radiation).

Results Of 133 SPECT/CT studies, the recognized HRD was less accurate (P< 0.001) in SPECT alone (118) & planar (109). Certainty of HRD was decreased (p< 0.001) in planar (69) & SPECT (102) than SPECT/CT (133). ES was seen in 18 MAAS by SPECT/CT (stomach, duodenum, pancreas, spleen or combinations), of which significantly less correct ES was observed in planar (9) & SPECT alone (13). Certainty of ES was notably less (p< 0.001) in planar (56) & SPECT (76) than SPECT/CT (132).

Conclusions SPECT/CT imaging allows correct anatomic identification of intra & extrahepatic MAA distribution & if possible should always be obtained during MAAS performed for YT planning. The markedly higher accuracy & certainty of SPECT/CT findings over planar or SPECT alone in our study may have been magnified by unusual liver configuration due to underlying pathology, tumor &/or prior therapy/resection.

  • © 2009 by Society of Nuclear Medicine
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Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
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The effectiveness of SPECT/CT in hepatic arterial Tc-99m MAA scan (MAAS) planning prior to hepatic Y-90 microsphere therapy (YT)
Sherif Heiba, Manli Jiang, J Weintraub, F. S. Nowakowski, P. Stangl, Anondo Stangl, Scott Nowakowski, Edward Kim, Karin Knesaurek, Zhuangyu Zhang, Josef Machac
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1663;

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The effectiveness of SPECT/CT in hepatic arterial Tc-99m MAA scan (MAAS) planning prior to hepatic Y-90 microsphere therapy (YT)
Sherif Heiba, Manli Jiang, J Weintraub, F. S. Nowakowski, P. Stangl, Anondo Stangl, Scott Nowakowski, Edward Kim, Karin Knesaurek, Zhuangyu Zhang, Josef Machac
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1663;
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