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Journal of Nuclear Medicine

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Meeting ReportGeneral Clinical Specialties: Musculoskeletal

99mTc-albumin nanocolloid (NC) joint scintigraphy in rheumatoid arthritis patients who are in clinical remission

Haim Golan, Olga Volkov, Oleg Lysyy, Ofer Levi and Moshe Tishler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1353;
Haim Golan
1Assaf Harofeh Medical Center affilliated to Tel-Aviv University, Nuclear Medicine Dept., Beer-Yaakov, Israel
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Olga Volkov
1Assaf Harofeh Medical Center affilliated to Tel-Aviv University, Nuclear Medicine Dept., Beer-Yaakov, Israel
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Oleg Lysyy
1Assaf Harofeh Medical Center affilliated to Tel-Aviv University, Nuclear Medicine Dept., Beer-Yaakov, Israel
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Ofer Levi
2Assaf Harofeh Medical Center affilliated to Tel-Aviv University, Internal Medicine Ward B, Beer-Yaakov, Israel
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Moshe Tishler
2Assaf Harofeh Medical Center affilliated to Tel-Aviv University, Internal Medicine Ward B, Beer-Yaakov, Israel
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Abstract

1353

Objectives To find out whether the clinical criteria in rheumatoid arthritis truly categorize patients to be in remission or that some patients still have subclinical active joint disease.

Methods 40 RA patients in clinical remission were studied.A comparison between the clinical criteria and the imaging results with 99mTc-NC scintigraphy was carried out.The clinical status of the patients was not known to the nuclear physician and scan visual interpretation was carried out while blinded to any laboratory or clinical data.Each patient was given an intravenous injection of 555 MBq of 99mTc-NC 1-h prior to spot views of the wrists, hands, shoulders, pelvic joints and SPECT-CT of the wrists and hands.A scan was considered positive when the joint showed increased tracer uptake, irrespective of the number of positive joints, while diffuse tracer activity with no focal joint uptake was regarded as negative.

Results The patients consisted of 29 females and 11 males, mean age of 60.8 years (range 22-86 years) disease duration of 13.4 years (3-23 years) and mean remission 27 months (12-48 months).The 99mTc-NC scintigraphy was negative in 16 and positive in 24.22 patients with positive scans were RF positive and 2 were sero-negative, while in those who had a negative scintigraphy only 2 patients were sero- positive while the others were sero-negative.

Conclusions The results of this study indicate that the clinical criteria used for remission in RA are not consistent with the actual inflammatory joint activity shown by 99mTc-albumin nanocolloid.

  • © 2009 by Society of Nuclear Medicine
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Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
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99mTc-albumin nanocolloid (NC) joint scintigraphy in rheumatoid arthritis patients who are in clinical remission
Haim Golan, Olga Volkov, Oleg Lysyy, Ofer Levi, Moshe Tishler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1353;

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99mTc-albumin nanocolloid (NC) joint scintigraphy in rheumatoid arthritis patients who are in clinical remission
Haim Golan, Olga Volkov, Oleg Lysyy, Ofer Levi, Moshe Tishler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1353;
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