Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Meeting ReportNeurosciences: Basic Science

Detection of alcohol-induced dopamine release in alcohol-preferring (P) rats using 11C-raclopride and PET

J Sullivan, Marc Normandin, Janice Froehlich and Evan Morris
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1208;
J Sullivan
1Purdue U, West Lafayette, IN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marc Normandin
1Purdue U, West Lafayette, IN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janice Froehlich
3IU Med Sch, Indianapolis, IN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Evan Morris
2Purdue Sch of Eng & Tech, Indianapolis, IN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

1208

Objectives Microdialysis has been used to demonstrate that ethanol produces an increase in extracellular dopamine (DA) in the striatum of rats (Heidbreder & De Witte, 1993). The present study examined whether or not similar changes in striatal DA can be detected in P rats using small animal PET.

Methods PET images were acquired from 8 alcohol-naïve male P rats. Rats received three 11C-raclopride scans (at rest, following alcohol, following saline). Scans were performed on IndyPETIII (approx. 1 mm FWHM in-plane). Prior to each scan, rats were anesthetized with 5% isoflurane, secured on a stereotaxic holder, and maintained on 1.5% isoflurane during the scan. P rats received 2.25 g ethanol/kg BW (15% v/v, IP) 5 minutes before tracer injection. Blood samples were collected from the lateral saphenous vein (n=7) 10 min after tracer injection to determine blood alcohol content (BAC) which was 197 mg% ± 26mg% (mean ± SEM). Time activity curves were extracted from striatum and cerebellum and binding potentials (BP) were calculated by a Logan reference technique (Ichise, 2002; Logan, 1996).

Results Alcohol decreased BP by 6.6 ± 6.6% (n=8, p<0.35) whereas saline decreased BP by only 0.72% ± 7.3% (n=8, p<0.83). BAC was positively correlated with decreased BP (r=0.78, p<0.04). Large decreases in BP were observed only in rats with BACs above 200 mg%.

Conclusions Alcohol-induced DA release may be detectable in the striatum of P rats via small animal PET, but a BAC of 200mg% or greater is likely needed in order to induce a significant release of DA in the striatum.

Research Support P60 AA007611-16

  • © 2009 by Society of Nuclear Medicine
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Detection of alcohol-induced dopamine release in alcohol-preferring (P) rats using 11C-raclopride and PET
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Detection of alcohol-induced dopamine release in alcohol-preferring (P) rats using 11C-raclopride and PET
J Sullivan, Marc Normandin, Janice Froehlich, Evan Morris
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1208;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Detection of alcohol-induced dopamine release in alcohol-preferring (P) rats using 11C-raclopride and PET
J Sullivan, Marc Normandin, Janice Froehlich, Evan Morris
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1208;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Neurosciences: Basic Science

  • Neural correlates of opiate abuse differ in adolescent compared to adult animals
  • Cerebrocortical plasticity after acute and chronic unilateral lesion of the central vestibular system in rats: A Micro-PET study
  • Differential brain metabolism following single vs. repeated ethanol exposures in adolescent rat: A [18F]fluorodeoxyglucose-PET study
Show more Neurosciences: Basic Science

Basic Science Posters

  • Investigation of new 32P-CP-PLLA microparticle in the treatment of pancreatic cancer mice
  • Radiolabeled inhibitors of seprase targeting the tumor microenvironment
  • Toward high affinity VEGFR2 binding helix bundles
Show more Basic Science Posters

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire