PET-Based Biodistribution and Radiation Dosimetry of Epidermal Growth Factor Receptor–Selective Tracer 11C-PD153035 in Humans

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
FIGURE 1.
Representative coronal images of whole-body biodistribution of ¹¹C-PD153035 30–40 min after injection (292.3 MBq) in healthy volunteer. Intense tracer uptake was observed in liver, gallbladder, urinary bladder, and kidneys. (A) CT image. (B) PET image.
Download figure
Open in new tab
Download powerpoint
FIGURE 2.
¹¹C-PD-153035 PET/CT scan in patient with NSCLC of left lung. (A) Coronal CT image. (B) Coronal PET image. (C) Transaxial CT image. (D) Transaxial PET image.
Download figure
Open in new tab
Download powerpoint
FIGURE 3.
(A) Time–activity curves for ¹¹C-PD153035 in serial PET of gallbladder, bladder, small intestine, and ureter. Data points indicate measured mean activities and were not corrected for radioactive decay. (B) Time–activity curves for ¹¹C-PD153035 in serial PET of liver, kidneys, brain, lungs, heart, and spleen. Data points indicate measured mean activities and were not corrected for radioactive decay.

TABLE 1

Subject Characteristics

Subject or parameter	Age (y)	Height (cm)	Weight (kg)	Injected dose (MBq)	Sex
1	31	168	62	314.5	F
2	21	178	73	292.3	M
3	29	174	82	447.7	M
4	32	176	72	436.6	M
5	31	158	61	240.5	F
6	28	165	64	303.4	F
7	27	169	63	281.2	F
8	31	174	75	251.6	M
9	25	163	69	395.9	F
Mean ± SD	28.3 ± 3.8	169.4 ± 6.6	65.4 ± 7.7	329.3 ± 77.8

TABLE 2

Mean Radiation-Absorbed Dose Estimates for ¹¹C-PD153035

	Mean ± SD radiation-absorbed dose (mGy/MBq)
Organ or parameter	Men	Women	Average
Adrenal glands	1.10E−03 ± 9.49E−05	1.05E−03 ± 1.42E−04	1.07E−03 ± 1.19E−04
Brain	3.92E−04 ± 1.07E−04	3.43E−04 ± 1.88E−04	3.65E−04 ± 1.50E−04
Gallbladder wall	2.69E−02 ± 1.10E−02	2.16E−02 ± 4.74E−03	2.40E−02 ± 8.01E−03
Small intestine	5.38E−03 ± 9.00E−05	6.00E−03 ± 1.82E−03	5.73E−03 ± 1.33E−03
Heart wall	1.79E−03 ± 3.62E−04	2.03E−03 ± 8.05E−04	1.93E−03 ± 6.24E−04
Kidneys	1.62E−02 ± 7.02E−03	1.25E−02 ± 6.06E−03	1.42E−02 ± 6.36E−03
Liver	8.93E−03 ± 1.71E−03	9.24E−03 ± 1.78E−03	9.10E−03 ± 1.65E−03
Lungs	4.10E−04 ± 3.62E−05	4.41E−04 ± 9.00E−05	4.27E−04 ± 6.93E−05
Muscles	5.21E−04 ± 1.09E−04	6.35E−04 ± 8.93E−05	5.84E−04 ± 1.10E−04
Pancreas	1.45E−03 ± 2.33E−04	1.52E−03 ± 2.99E−04	1.49E−03 ± 2.58E−04
Red marrow	7.29E−04 ± 6.42E−05	7.53E−04 ± 1.19E−04	7.42E−04 ± 9.37E−05
Spleen	2.32E−03 ± 2.85E−04	2.72E−03 ± 1.31E−03	2.54E−03 ± 9.68E−04
Urinary bladder wall	4.93E−02 ± 1.90E−02	7.00E−02 ± 1.32E−02	6.08E−02 ± 1.85E−02
Ovaries		1.87E−03 ± 3.25E−04	1.87E−03 ± 3.25E−04
Testes	7.23E−04 ± 2.67E−04		7.23E−04 ± 2.67E−04
Effective dose equivalent (mSv/MBq)	6.94E−03 ± 1.38E−03	7.82E−03 ± 7.33E−04	7.43E−03 ± 1.10E−03
Effective dose (mSv/MBq)	3.98E−03 ± 1.21E−03	5.24E−03 ± 8.40E−04	4.68E−03 ± 1.16E−03