99TcmN-NOET SPECT in diagnosis of lung neoplasms

Abstract

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Objectives: To investigate the method of 99TcmN-NOET lung imaging and its value for diagnosis of lung neoplasms.

Methods: CT, early and delay 99TcmN-NOET SPECT imaging were performed on 61 pts suspected with lung lesion before operated. The characters of the nodules were defined by images and the semiquantitative measurements of the early T/N ratio (ER) and delayed T/N ratio (DR) .The result was compared with pathological.

Results: Fifty-one pts was found be with malignancy of lung,whereas 10 cases with benign diseases. The value of ER in malignant and benign group was 1.25±0.15 and 1.09±0.11; the value of DR was 1.40±0.17 and 1.18±0.21, the difference was significant respectively (P<0.001). The retention index (RI%) of two groups was 11.5±7.65 and 8±10.9, there was no significant difference (p>0.05). Examination with NOET SPECT showed a diagnostic sensitivity of 94.1%, specificity of 70%, positive predictive value of 94.1%, negative predictive value of 70%, and accuracy of 90.2%. Results of CT gave a sensitivity, specificity,positive predictive value,negative predictive value and ofaccuracy is 90.2%, 80%,95.8%,61.5 %,and 88.5%.

Conclusions: 99TcmN-NOET SPECT may be a new method to differentiating benign and malignant pulmonary nodules and more sensitive than CT, however, more extensive studies should be performed to confirm the clinical role of 99TcmN-NOET.

T/N and RI% of two groups