Article Figures & Data
Figures
- FIGURE 1.
Proposed translational model in which interactive experiments with biomarker readouts are included in successively refined mathematic biologic or pharmacologic model. This concept is pursued from cellular studies, via xenografts, to plan and interpret human trial data.
- FIGURE 2.
Experimental data on growth of viable volume of spheroids without and with 2-h pulse treatment with NVP-AUY922 at different concentrations. Data are normalized to pretreatment volume. Error bars indicate SEM.
- FIGURE 3.
Experimental data of spheroid growth (points) are fitted to mathematic model (full lines).
- FIGURE 4.
Growth inhibition as extracted from model is plotted vs. time after exposure, for different exposures.
- FIGURE 5.
Based on model, growth patterns are simulated with once-per-week treatment schedule, for 3 different exposures.
- FIGURE 6.
Drug effect on 18F-FLT (A) and 18F-FDG (B) uptake at different times after pulse treatment with 3 different exposures.
- FIGURE 7.
Induced reduction of 18F-FLT uptake plotted against derived growth inhibition for all different time points and dose exposures. Full line indicates fitted sigmoid curve.
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