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Category No. % Age (y)* All 76 100 >50 25 32.9 20–50 45 59.2 <20 6 7.9 Sex Female 61 80.3 Male 15 19.7 Ethnicity Caucasian 63 82.9 African American 9 11.8 Asian 1 1.3 Hispanic 1 1.3 Not stated 2 2.6 Smoking† Yes 8 10.5 No 68 89.5 ATD‡ Yes 19 25.0 No 57 75.0 TSI index ≤1.8 14 18.4 >1.8§ 34 44.7 All 48 63.1 FT3 (pmol/L)‖ <16.6 31 40.8 ≥16.6 28 36.8 All 59 77.6 ↵* Age in years: mean, 42.9; SD, 14.8; range, 10.6–72; median, 44.
↵† Cigarette smoking during previous year or during study.
↵‡ Methimazole or propylthiouracil. Discontinued at least 3 d before 131I therapy.
↵§ Level considered positive and reflective of Graves' disease.
↵‖ Upper limit of normal, 8.3 pmol/L.
No. patients affected compared with baseline No. patients (baseline) 2 mo 6 mo 1 y Item* New Disappear Net change New Disappear Net change New Disappear Net change CAS items Pain Pain on/behind globe 6 2 4 −2 3 5 −1 2 5 −3 Pain with eye movement 5 4 5 −1 0 5 −5 0 5 −5 Redness Eyelids 2 1 2 −1 0 2 −2 0 1 −1 Diffuse conjunctival 14 7 11 −4 6 1 −4 9 11 −2 Swelling Eyelids 13 4 8 −4 5 7 −2 5 9 −4 Chemosis 5 3 4 −1 7 5 2 3 4 −1 Caruncle 1 2 0 1 1 1 0 1 1 0 Proptosis (Hertel exophthalmometer†) ‡ 18 16 30 Impaired vision Extraocular movement (diplopia) 15 7 6 1 9 7 2 13 10 3 Visual acuity —‡ 0 0 0 Total no. patients evaluated 76 72 69 76 2 mo 6 mo 1 y CAS points Total points 48 47 63 Mean 0.63 0.62 0.83§ SD 1.02 0.97 1.01 No. patients Any points 31 30 41 ≥2 points 10 11 15 Baseline 1 y Difference Patient R L R L R L All patients (n = 76) Mean 18.1 18.2 18.8 18.8 0.8 0.6 SD 3.0 2.7 3.2 3.3 1.9 1.9 All patients without change (n = 36) Mean† 18.1 17.9 18.1 17.9 0.0 −0.1 SD 2.7 2.4 2.7 2.5 0.8 0.7 Patients with ≥2 mm change (n = 30) Mean† 17.7 17.9 20.2 20.3 2.6 2.5 SD 3.2 2.6 3.1 2.8 1.1 1.3 Patients with ≤2 mm change (n = 10) Mean† 19.7 19.9 17.8 17.5 −1.9 −2.5 SD 3.3 3.3 3.6 6.8 1.7 0.9 2 mo 6 mo 1 y Baseline New Disappear Net change New Disappear Net change New Disappear Net change 16 6 3 3 6 7 −1 8 2 6 ↵* Based on age, sex, and ethnicity data from previous publications (14–17).
- TABLE 5
Associations of Covariates and CAS Points and Covariates and Exophthalmometer Readings at 1 Year
No. patients with CAS points… No. patients with exophthalmometer reading of… Covariate No. patients with covariate <2 ≥2 P <2 mm ≥2 mm P Hyperthyroidism ≤2.5 mo 65 55 10 0.035 41 24 0.326 >2.5 mo 11 6 5 5 6 Hypothyroidism ≤0.5 mo 61 50 11 0.478 35 26 0.378 >0.5 mo 15 11 4 11 4 Smoking No 68 56 12 0.188 43 25 0.252 Yes 8 5 3 3 5 ATD No 57 45 12 0.748 34 23 1.000 Yes 19 16 3 12 7 TSI ≤1.8 mo 15 12 3 1.000 11 4 0.526 >1.8 mo 34 29 5 21 13 FT3 ≤16.6 pmol/L 31 27 4 0.320 21 10 0.598 >16.6 pmol/L 28 21 7 17 11 QOL Questionnaire for Patients with Graves' Eye Disease
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