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Meeting ReportGeneral Clinical Specialties: Endocrinology

Serum thyrotrophic-receptor auto antibodies levels after 131I therapy in Graves’ patients and effect of pretreatment with ATD

Liu Jianzhong and An Caixia
Journal of Nuclear Medicine May 2007, 48 (supplement 2) 274P;
Liu Jianzhong
1Nuclear Medicine, No.1 Hospital of Shanxi Medical University, Taiyuan, China
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An Caixia
1Nuclear Medicine, No.1 Hospital of Shanxi Medical University, Taiyuan, China
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Abstract

1236

Objectives: there is a transitory increase in levels of thyrotrophic receptors antibodies (TRAb) after radioiodine therapy (131I) in hyperthyroid Graves disease,Immunosuppressive effects of anti thyroid drugs (ATD) are still a matter of debate. In this study we evaluated the effect of anti thyroid drug pretreatment on the TRAb boost induced by 131I. Methods: 41 patients were assigned to receive 131I alone (18 patients) or 131I plus pretreatment with ATD (23 patients). Serum TRAb levels measured on the day of 131I dosing (D0), and at 3 and 6 12 months after 131I administration. half a year after follow-up,there is three prognosis: hyperthyroid (Hyper-group); euthyroid(Eu-group); and hypothyroid (Hypo-group). Results: 1. Before 131I treatment, there is no different in TRAb levels between patients treated with ATD and 131I alone group: 39.95±42.88 U/l, 46.08±51.80 U/l, P>0.05. After 131I treatment, in patients treated with ATD, TRAb levels increased significantly from D0 to 3rd month 39.95±42.88 U/l, 204.32±134.19 U/l, P<0.05 reaching their highest levels at 3rd months. After this, we observed a progressive decrease at 6th months (81.30±92.07U/l). In patients treated with 131I alone, TRAb levels increased at 3rd month 117.86±103.36 vs. 46.08±51.80 U/l; P<0.05. And at 6th months compared with D0 values 105.30±97.70 vs. 46.08±51.80 U/l; P<0.05. After this, we observed a progressive decrease at 6th months. The course of TRAb levels after 131I treatment was significantly different between the two groups (P>0.05). 2. The course of TRAb levels after 131I treatment was significantly different in the three different prognosis groups (P<0.05). A higher TRAb level before 131I treatment was associated with hyperthyroidism after half a year of follow-up. Conclusions: (1)Radioiodine therapy (131I) in hyperthyroid Graves’ disease followed by a transitory increase in levels of TRAb; (2)ATD pretreatment don’t attenuates the 131I -induced rise in serum TRAb levels. (3) high TRAb levels before 131I are associated with a relative resistance to therapy; there is no decrease in TRAb levels between the 3rd and the 6th month after 131I are associated with hypothyroid after half a year of follow-up.

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Journal of Nuclear Medicine
Vol. 48, Issue supplement 2
May 1, 2007
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Serum thyrotrophic-receptor auto antibodies levels after 131I therapy in Graves’ patients and effect of pretreatment with ATD
Liu Jianzhong, An Caixia
Journal of Nuclear Medicine May 2007, 48 (supplement 2) 274P;

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Serum thyrotrophic-receptor auto antibodies levels after 131I therapy in Graves’ patients and effect of pretreatment with ATD
Liu Jianzhong, An Caixia
Journal of Nuclear Medicine May 2007, 48 (supplement 2) 274P;
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